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Table 7 Pathways enrichment analysis in communities and their associated weights

From: Consensus strategy in genes prioritization and combined bioinformatics analysis for preeclampsia pathogenesis

Pathways

PathRankScore k

N Community

PathGeneScore m

PathScore m

Community

VEGF signaling pathway

89,07

1

0,422

0,547

2

mTOR signaling pathway

130,18

2

0,445

0,505

2,6

Adipocytokine signaling pathway

169,98

3

0,518

0,479

1,2,8

Intestinal immune network for IgA production

171,28

1

0,497

0,467

6

Leukocyte transendothelial migration

89,07

1

0,303

0,463

2

Progesterone-mediated oocyte maturation

89,07

1

0,301

0,462

2

Cytokine-cytokine receptor interaction

185,95

4

0,529

0,455

1,2,4,6

Jak-STAT signaling pathway

176,12

4

0,468

0,445

1,2,8,9

Renin-angiotensin system

231,04

1

0,804

0,443

5

MAPK signaling pathway

149,87

2

0,378

0,439

8,9

Complement and coagulation cascades

225,19

3

0,708

0,432

4,5,6

TGF-beta signaling pathway

190,97

2

0,486

0,427

6,8

Focal adhesion

188,28

3

0,464

0,422

2,6,7

Apoptosis

194,56

1

0,431

0,396

9

Regulation of actin cytoskeleton

171,28

1

0,326

0,378

6

Natural killer cell mediated cytotoxicity

210,67

1

0,453

0,375

8

ErbB signaling pathway

210,67

1

0,451

0,374

8

Fc epsilon RI signaling pathway

210,67

1

0,450

0,374

8

T cell receptor signaling pathway

210,67

1

0,436

0,368

8

Neurotrophin signaling pathway

202,61

2

0,339

0,338

8,9

Toll-like receptor signaling pathway

226,16

3

0,432

0,335

4,8,9

NOD-like receptor signaling pathway

241,96

2

0,510

0,326

4,8

Dorso-ventral axis formation

210,67

1

0,331

0,321

8

B cell receptor signaling pathway

210,67

1

0,328

0,319

8

Cell cycle

194,56

1

0,252

0,303

9

Chemokine signaling pathway

231,37

3

0,370

0,300

1,4,8

Gap junction

231,04

1

0,351

0,293

5

Calcium signaling pathway

237,48

2

0,363

0,284

3,5

Neuroactive ligand-receptor interaction

237,48

2

0,343

0,276

3,5

Vascular smooth muscle contraction

237,48

2

0,327

0,270

3,5

Melanogenesis

231,04

1

0,281

0,262

5

ECM-receptor interaction

304,50

1

0,478

0,040

7