Fig. 4

Mapping eigengenes to phenotypes. We inferred relationships between eigengenes and clinical parameters using a linear mixed-effect model, accounting for within-patient variance, and controlling for age, sex, race, diabetes, ischemic etiology, platelet transfusion, device type, plasmapheresis, and immunosuppression. We bi-clustered on the signed -log p-values to identify patterns, while displaying significant q-values. Note that the SOFA and MELD-XI scores are positively correlated with the innate (brown) and metabolic (blue) superclusters, and negatively correlated with the adaptive (turquoise) superclusters. Conversely, platelet count is positively correlated with the adaptive (turquoise) supercluster, while negatively correlated with the innate (brown) supercluster. Finally, the mitochondria module, which relates to both immunity superclusters, is associated with multiple indicators of organ failure