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Fig. 6 | BMC Medical Genomics

Fig. 6

From: Integrative model of leukocyte genomics and organ dysfunction in heart failure patients requiring mechanical circulatory support: a prospective observational study

Fig. 6

Hypothesis Linking PBMC-Mediated Inflammation, Organ Dysfunction and Death: In heart failure (HF)-patients requiring mechanical circulatory support (MCS) surgery, the time-dependently activated and well orchestrated innate inflammatory activation (as measured by time-series PBMC-transcriptome data and hypothetical interaction with endothelial cells (EC) and platelets (PLT)) and related organ dysfunction either serves to restore improved oxygen delivery, “cooling down” of inflammation, normalization of organ function, recovery and survival, or escalates and leads to death

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