Table 2 Summary of timecourse features
|  | Day −1 | Day +1 | Day +3 | Day +5 | Day +8 |
|---|---|---|---|---|---|
Upregulated phenotype | MELD-XI, bilirubin, temperature, PaO2/FiO2 | SOFA, creatinine | WBC | MAP, INR, platelets | Platelets, temperature, INR, glucose, respiratory rate |
Downregulated phenotype | WBC, MAP | Respiratory rate, temperature, platelets, MAP, PaO2/FiO2 | Glucose, INR | MELD-XI, SOFA, creatinine, glucose, heart rate | SOFA, bilirubin, creatinine |
Upregulated eigengene | Type I IFN, Transcription | Metabolic, mitochondria, innate | B cells, transcription | Mitosis, Defense, RNA processing | Apoptosis, protein folding, coagulation, catabolism |
Downregulated eigengene | Mitosis, catabolism, defense, mitochondria, ribosome | T cells, demethylation, ER, transcription, coagulation, Type I IFN, NK cells | Type I IFN, NK cells | Innate | B cells, innate, metabolic, mitochondria |