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Fig. 12 | BMC Medical Genomics

Fig. 12

From: De novo assembly and characterization of breast cancer transcriptomes identifies large numbers of novel fusion-gene transcripts of potential functional significance

Fig. 12

Structure of in-frame gene-fusion mutations resulting in gain of signaling protein domains (trans-membrane and/or signal peptide domains) from another participating gene. Depicted are 12 of 15 detected fusion events where genes were not previously associated with the signaling/TM functions. Gene symbols and corresponding chromosomes (in parenthesis) are shown above each gene fusion structure. Gene symbols are defined as follows: (a) SCNN1G: Sodium Channel, Non-Voltage-Gated 1, Gamma Subunit; COl27A1L: Collagen, Type XXVII, Alpha 1; (b) SLC35B1: Solute Carrier Family 35, Member B1; IGFBP4: Insulin-Like Growth Factor Binding Protein 4; (c) KDM5A: Lysine (K)-Specific Demethylase 5A; ANO2: Anoctamin 2; (d) MDM1: Mdm1 Nuclear Protein Homolog (Mouse); ABCC1: ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 1; (e) VMP1: Vacuole Membrane Protein 1; RP11-433C9.2: Clone based putative protein coding gene on chromosome 3; (f) IGSF3: Immunoglobulin Superfamily, Member 3; NAP1L2: Nucleosome Assembly Protein 1-Like 2; (g) PODXL2: Podocalyxin-Like 2; PAXIP1: PAX Interacting (With Transcription-Activation Domain) Protein 1; (h) ANKLE2: Ankyrin Repeat And LEM Domain Containing 2; NHP2L1: NHP2 Non-Histone Chromosome Protein 2-Like 1 (S. cerevisiae); (i) NMT2: N-Myristoyltransferase 2; ITGA8: Integrin, Alpha 8; (j) SLC24A1: Solute Carrier Family 24 (Sodium/Potassium/Calcium Exchanger), Member 1; SMARCA4: SWI/SNF Related, Matrix Associated, Actin Dependent Regulator Of Chromatin, Subfamily A, Member 4; (k) PTPRK: Protein Tyrosine Phosphatase, Receptor Type, K; STXBP6: Syntaxin Binding Protein 6 (Amisyn); (l) TRIO: trio Rho guanine nucleotide exchange factor; MARCH11: Membrane-Associated Ring Finger (C3HC4) 11

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