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Fig. 13 | BMC Medical Genomics

Fig. 13

From: De novo assembly and characterization of breast cancer transcriptomes identifies large numbers of novel fusion-gene transcripts of potential functional significance

Fig. 13

Fusion-protein transcripts have higher expression than 3′-truncated proteins. Chimeric transcripts resulting in 3′-trunctated proteins are likely to produce non-functional transcripts and undergo non-sense mediated decay. Fusion-proteins where the open-reading frame of the participating gene is maintained, on the other hand, are expected to have higher expression than 3′-truncated chimers. The figure shows statistically higher (p-value: 0. 005, Student t-test one-tailed) expression for breast cancer specific fusion-protein transcripts (left) than for the 3′-truncated chimeric transcripts (right). Normalized read counts are used as expression estimates. Errors bars shown here are standard errors derived from the expression value distribution across chimer transcript in each category

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