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Fig. 16 | BMC Medical Genomics

Fig. 16

From: De novo assembly and characterization of breast cancer transcriptomes identifies large numbers of novel fusion-gene transcripts of potential functional significance

Fig. 16

Potential pro-neoplastic gene-fusions that are functionally suppressed in normal breast tissues but activated in cancer tissues. Shown is the structure of five gene-fusions and associated protein domains that we have characterized as potential pro-neoplastic fusions. Square boxes with numbers represent exons (5′ gene: orange, 3′ gene: blue); exons not shown in the figure are represented by a dashed empty box; the red star represents the fusion point for each fusion; gene symbols and (chromosomal location), as well as, the number of each fusion transcript detected in normal (N) and cancer (C) samples is presented above each gene-fusion structure. Protein domains are displayed under each structure. Histograms on the right display average expression levels of the 3′ members of the fusions in their native or parental (pre-fusion) genes in normal samples (blue) and the expression of the fusion transcript in cancer samples (orange) bar. Fold change is shown under each expression plot. All of the 3′ partners of these fusion transcripts have been previously associated with cancer progression (see text for details). (a) ZBTB47-FGD1 = zinc finger and BTB domain containing 47 gene fused with FYVE, RhoGEF and PH domain-containing protein 1 gene; (b) KRI1-ATRX = KRI 1 homolog gene fused with ATP-dependent helicase ATRX gene; (c) SCAF4-TNRC6A = SR-related CTD associated factor 4 gene fused with trinucleotide repeat-containing gene 6A; (d) CACNA1D-CTNNBL1 = calcium channel, voltage-dependent, L type, alpha 1D subunit gene fused with the catenin beta like 1 gene; and (e) ACHE1-CES4A = acetylcholinesterase 1 gene fused with carboxylesterase 4A gene

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