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Table 7 Distribution of chimeric transcripts across breast cancer subtypes

From: De novo assembly and characterization of breast cancer transcriptomes identifies large numbers of novel fusion-gene transcripts of potential functional significance

Chimer Functional Class ER+/HER2+ only Triple negative only Common Totala
Fusion-protein 59 18 1 79
3′ UTR change 111 33 11 166
5′ UTR change 31 10 2 45
3′ truncated protein 294 107 9 419
cryptic splice-site 292 133 8 441
novel RNA 265 100 10 385
Overall 1052 401 41 1535
  1. Number of breast cancer specific (not detected in normal tissues) chimeric transcripts from different functional classes in breast cancer subtypes. Two major subtype groups were defined. ER+/HER+ is where patient is either ER+ or HER2+ or both; triple negative where patient is ER-, PR- and HER2-. aTotal: Common transcripts are counted twice since they are present in both subtype groups