|
Chimer Functional Class
|
ER+/HER2+ only
|
Triple negative only
|
Common
|
Totala
|
|---|
|
Fusion-protein
|
59
|
18
|
1
|
79
|
|
3′ UTR change
|
111
|
33
|
11
|
166
|
|
5′ UTR change
|
31
|
10
|
2
|
45
|
|
3′ truncated protein
|
294
|
107
|
9
|
419
|
|
cryptic splice-site
|
292
|
133
|
8
|
441
|
|
novel RNA
|
265
|
100
|
10
|
385
|
|
Overall
|
1052
|
401
|
41
|
1535
|
- Number of breast cancer specific (not detected in normal tissues) chimeric transcripts from different functional classes in breast cancer subtypes. Two major subtype groups were defined. ER+/HER+ is where patient is either ER+ or HER2+ or both; triple negative where patient is ER-, PR- and HER2-. aTotal: Common transcripts are counted twice since they are present in both subtype groups
