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Table 7 Distribution of chimeric transcripts across breast cancer subtypes

From: De novo assembly and characterization of breast cancer transcriptomes identifies large numbers of novel fusion-gene transcripts of potential functional significance

Chimer Functional Class

ER+/HER2+ only

Triple negative only

Common

Totala

Fusion-protein

59

18

1

79

3′ UTR change

111

33

11

166

5′ UTR change

31

10

2

45

3′ truncated protein

294

107

9

419

cryptic splice-site

292

133

8

441

novel RNA

265

100

10

385

Overall

1052

401

41

1535

  1. Number of breast cancer specific (not detected in normal tissues) chimeric transcripts from different functional classes in breast cancer subtypes. Two major subtype groups were defined. ER+/HER+ is where patient is either ER+ or HER2+ or both; triple negative where patient is ER-, PR- and HER2-. aTotal: Common transcripts are counted twice since they are present in both subtype groups