Chimer Functional Class | ER+/HER2+ only | Triple negative only | Common | Totala
|
---|
Fusion-protein | 59 | 18 | 1 | 79 |
3′ UTR change | 111 | 33 | 11 | 166 |
5′ UTR change | 31 | 10 | 2 | 45 |
3′ truncated protein | 294 | 107 | 9 | 419 |
cryptic splice-site | 292 | 133 | 8 | 441 |
novel RNA | 265 | 100 | 10 | 385 |
Overall | 1052 | 401 | 41 | 1535 |
- Number of breast cancer specific (not detected in normal tissues) chimeric transcripts from different functional classes in breast cancer subtypes. Two major subtype groups were defined. ER+/HER+ is where patient is either ER+ or HER2+ or both; triple negative where patient is ER-, PR- and HER2-. aTotal: Common transcripts are counted twice since they are present in both subtype groups