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Fig. 4 | BMC Medical Genomics

Fig. 4

From: A systematic review and integrative approach to decode the common molecular link between levodopa response and Parkinson’s disease

Fig. 4

Crosstalk between the genes (in blue) obtained from the systematic review of LR and their biological functions in the dopaminergic neurons. Levodopa is metabolized by COMT and DDC. Dopamine in the pre-synaptic neuron is produced from and released into the synapse by exocytosis. The receptors in the post-synaptic neurons [DRD1, DRD2, DRD3, ADORA2, glutamate receptors (mGLUR1/S), NMDA, HTR2A] uptake dopamine and further downstream cellular signalling leads to altered gene expression. Signalling pathways like the Ras-GRF1 mediated signalling, Ca2+-calmodulin dependent pathway and adenylyl cyclase participate in dopaminergic response. The function of 6 common genes (in bold) found with overlapping roles in LR and PD risk are discussed in text

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