Fig. 6
From: Analysis of viral diversity for vaccine target discovery
Distribution in nature of hepatitis A virus (HAV) protein nonamers. Nonamers of HAV are found across viruses, archaea, bacteria, and eukaryota kingdoms. Picornaviridae are viruses of the same family as HAV. HAV is a single stranded RNA virus that encodes for four structural proteins, namely 1A (VP4), 1B (VP2), 1C (VP3), and 1D (VP1), and seven non-structural proteins (2A, 2B, 2C, 3A, 3B, 3C and 3D). The length of the protein bars indicate the number of nonamers of these protein that are matched by the other species. Highly conserved nonamers that do not match any one of the species, in particular the co-circulating viruses are favourable for selection as potential vaccine targets in order to avoid potential altered ligand effects