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Table 1 Functional annotation of the hub genes in ovarian cancer

From: Identification of prognostic signature in cancer based on DNA methylation interaction network

Pathways p-value FDR q-value
Pathways in cancer 2.89E-24 5.37E-22
MAPK signaling pathway 4.17E-16 3.88E-14
Wnt signaling pathway 1.23E-13 7.62E-12
p53 signaling pathway 5.23E-13 2.43E-11
Prostate cancer 3.97E-12 1.48E-10
Cell cycle 4.97E-12 1.54E-10
Endocytosis 9.75E-12 2.59E-10
Neurotrophin signaling pathway 1.81E-11 4.20E-10
Apoptosis 2.12E-11 4.38E-10
Small cell lung cancer 5.05E-11 9.40E-10
Leishmania infection 9.37E-11 1.58E-09
Cytokine-cytokine receptor interaction 3.45E-10 5.35E-09
Regulation of actin cytoskeleton 1.24E-09 1.77E-08
Purine metabolism 1.43E-09 1.90E-08
Jak-STAT signaling pathway 3.27E-09 4.06E-08
Ubiquitin mediated proteolysis 4.10E-09 4.77E-08
Toll-like receptor signaling pathway 8.42E-08 9.21E-07
Focal adhesion 1.06E-07 1.09E-06
Pyrimidine metabolism 1.98E-07 1.93E-06
Glycosphingolipid biosynthesis - lacto and neolacto series 4.40E-07 4.09E-06
Amyotrophic lateral sclerosis (ALS) 4.85E-07 4.29E-06
Neuroactive ligand-receptor interaction 5.23E-07 4.42E-06
T cell receptor signaling pathway 1.02E-06 8.22E-06
Alzheimer’s disease 1.14E-06 8.77E-06
Chronic myeloid leukemia 1.18E-06 8.77E-06
Phosphatidylinositol signaling system 2.08E-06 1.49E-05
Tight junction 2.48E-06 1.71E-05
NOD-like receptor signaling pathway 3.73E-06 2.47E-05
Non-small cell lung cancer 3.85E-06 2.47E-05
Melanoma 4.11E-06 2.47E-05
Spliceosome 4.21E-06 2.47E-05
Leukocyte transendothelial migration 4.24E-06 2.47E-05
Axon guidance 4.78E-06 2.69E-05
Lysosome 6.29E-06 3.44E-05
Glioma 6.73E-06 3.58E-05
B cell receptor signaling pathway 8.37E-06 4.33E-05
Oocyte meiosis 9.39E-06 4.72E-05
Base excision repair 9.77E-06 4.73E-05
VEGF signaling pathway 9.92E-06 4.73E-05
Epithelial cell signaling in Helicobacter pylori infection 1.17E-05 5.44E-05
Endometrial cancer 1.44E-05 6.53E-05
Colorectal cancer 1.94E-05 8.58E-05
  1. The p-value and FDR q-value was provided by GSEA, which was applied to evaluate the significance of the enrichment analysis