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Table 1 Functional annotation of the hub genes in ovarian cancer

From: Identification of prognostic signature in cancer based on DNA methylation interaction network

Pathways

p-value

FDR q-value

Pathways in cancer

2.89E-24

5.37E-22

MAPK signaling pathway

4.17E-16

3.88E-14

Wnt signaling pathway

1.23E-13

7.62E-12

p53 signaling pathway

5.23E-13

2.43E-11

Prostate cancer

3.97E-12

1.48E-10

Cell cycle

4.97E-12

1.54E-10

Endocytosis

9.75E-12

2.59E-10

Neurotrophin signaling pathway

1.81E-11

4.20E-10

Apoptosis

2.12E-11

4.38E-10

Small cell lung cancer

5.05E-11

9.40E-10

Leishmania infection

9.37E-11

1.58E-09

Cytokine-cytokine receptor interaction

3.45E-10

5.35E-09

Regulation of actin cytoskeleton

1.24E-09

1.77E-08

Purine metabolism

1.43E-09

1.90E-08

Jak-STAT signaling pathway

3.27E-09

4.06E-08

Ubiquitin mediated proteolysis

4.10E-09

4.77E-08

Toll-like receptor signaling pathway

8.42E-08

9.21E-07

Focal adhesion

1.06E-07

1.09E-06

Pyrimidine metabolism

1.98E-07

1.93E-06

Glycosphingolipid biosynthesis - lacto and neolacto series

4.40E-07

4.09E-06

Amyotrophic lateral sclerosis (ALS)

4.85E-07

4.29E-06

Neuroactive ligand-receptor interaction

5.23E-07

4.42E-06

T cell receptor signaling pathway

1.02E-06

8.22E-06

Alzheimer’s disease

1.14E-06

8.77E-06

Chronic myeloid leukemia

1.18E-06

8.77E-06

Phosphatidylinositol signaling system

2.08E-06

1.49E-05

Tight junction

2.48E-06

1.71E-05

NOD-like receptor signaling pathway

3.73E-06

2.47E-05

Non-small cell lung cancer

3.85E-06

2.47E-05

Melanoma

4.11E-06

2.47E-05

Spliceosome

4.21E-06

2.47E-05

Leukocyte transendothelial migration

4.24E-06

2.47E-05

Axon guidance

4.78E-06

2.69E-05

Lysosome

6.29E-06

3.44E-05

Glioma

6.73E-06

3.58E-05

B cell receptor signaling pathway

8.37E-06

4.33E-05

Oocyte meiosis

9.39E-06

4.72E-05

Base excision repair

9.77E-06

4.73E-05

VEGF signaling pathway

9.92E-06

4.73E-05

Epithelial cell signaling in Helicobacter pylori infection

1.17E-05

5.44E-05

Endometrial cancer

1.44E-05

6.53E-05

Colorectal cancer

1.94E-05

8.58E-05

  1. The p-value and FDR q-value was provided by GSEA, which was applied to evaluate the significance of the enrichment analysis