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Table 1 Analysis of differential mRNA expression of PD-L1, PD-L2 and JAK2 in tumors with PD-L1 CNG compared to tumors without PD-L1 CNG

From: Chromosome 9p copy number gains involving PD-L1 are associated with a specific proliferation and immune-modulating gene expression program active across major cancer types

Cancer type

PD-L1

PD-L2

JAK2

fold change

p

fold change

p

fold change

p

Lusc

4.9

1.60E-27

2.3

3.80E-13

1.8

3.70E-14

Blca

4.1

7.70E-14

2.6

2.80E-06

2

3.60E-14

Hnsc

2.9

1.30E-16

2.5

1.20E-14

2.1

7.10E-19

cesc

2.7

2.50E-08

2

9.00E-05

1.9

4.90E-07

skcm

2.2

0.0073

1.5

0.12

2

0.00026

paad

2

0.14

1.6

0.5

1.3

0.23

sarc

1.9

0.0028

2.2

0.00013

1.4

0.00042

luad

1.8

0.00078

1.2

0.12

1.4

7.60E-05

prad

1.8

9.00E-04

1.6

0.002

1.4

0.00017

stad

1.8

0.0026

1

0.79

1.4

0.0061

kirc

1.7

0.18

1

0.98

1.2

0.15

ov

1.7

5.20E-07

1.3

0.034

1.6

4.40E-12

kirp

1.6

0.44

1.1

0.87

1.3

0.45

thca

1.5

0.45

1.4

0.3

1.2

0.4

gbm

1.4

0.34

1.6

0.1

1.3

0.014

ucec

1.4

0.17

1.2

0.51

1.2

0.28

brca

1.3

0.016

1.3

0.002

1.3

2.40E-05

lihc

1.2

0.52

-1

0.91

1.5

0.0083

coadread

1.1

0.62

1.1

0.59

1.3

0.00038

lgg

-1

0.88

2.5

0.004

1.4

0.00027

pcpg

−2.6

0.27

−1.3

0.13

−1.2

0.48

  1. Significant changes (p < 0.05) are highlighted
  2. Investigated cancer types: Bladder Urothelial Carcinoma (BLCA), Breast invasive carcinoma (BRCA), Cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC), Colorectal adenocarcinoma (COADREAD), Glioblastoma multiforme (GBM), Head and Neck squamous cell carcinoma (HNSC), Kidney renal clear cell carcinoma (KIRC), Kidney Renal Papillary Cell Carcinoma (KIRP), Brain Lower Grade Glioma (LGG), Liver hepatocellular carcinoma (LIHC), Lung adenocarcinoma (LUAD), Lung squamous cell carcinoma (LUSC), Ovarian serous cystadenocarcinoma (OV), pancreatic adenocarcinoma (PAAD), Pheochromocytoma and Paraganglioma (PCPG), Prostate Adenocarcinoma (PRAD), Sarcoma (SARC), Skin Cutaneous Melanoma (SKCM), Stomach adenocarcinoma (STAD), Papillary Thyroid Carcinoma (THCA), and Uterine Corpus Endometrial Carcinoma (UCEC)
  3. Bold data indicate significance (p < 0.05)
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BMC Medical Genomics

ISSN: 1755-8794

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