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Table 4 The top-ranked predictions for selected diseases(Verification in CTD database)

From: Predicting drug-disease interactions by semi-supervised graph cut algorithm and three-layer data integration

Disease

Known drugs

Part of top-ranked predictions

Direct evidence

HD (143100)

Baclofen (DB00181)

Clozapine (DB00363, rank:01)

 
 

Tetrabenazine (DB04844)

Olanzapine (DB00334, rank:03)

T

  

Aripiprazole (DB01238, rank:06)

T

  

Amitriptyline (DB00321, rank:10)

 
  

Risperidone (DB00734, rank:12)

 

NSCLC (211980)

Doxorubicin (DB00997)

Carboplatin (DB00958, rank:01)

T

  

Adenosine triphosphate (DB00171, rank:02)

 
  

Glutathione (DB00143, rank:05)

 
  

Ponatinib (DB08901, rank:09)

 
  

Sorafenib (DB00398, rank:10)

 
  

Dasatinib (DB01254, rank:14)

 
  

Daunorubicin (DB00694, rank:15)

 
  

Epirubicin (DB00445, rank:16)

T

  

Bosutinib (DB06616, rank:18)

 
  

Caffeine (DB00201, rank:19)

 
  

Cisplatin (DB00515, rank:20)

T

AD (103780)

Citalopram (DB00215)

Lorazepam (DB00186, rank:04)

T

 

Chlordiazepoxide (DB00475)

Diazepam (DB00829, rank:10)

 
 

Acamprosate (DB00659)

Clomipramine (DB01242, rank:13)

 
 

Naltrexone (DB00704)

Flunitrazepam (DB01544, rank:14)

 
 

Disulfiram (DB00822)

Adenosine triphosphate (DB00171, rank:17)

 
 

Ondansetron (DB00904)

Trazodone (DB00656, rank:18)

 
  

Imipramine (DB00458, rank:20)

 

SCLC (182280)

Cisplatin (DB00515)

Carboplatin (DB00958, rank:01)

T

 

Methotrexate (DB00563)

Adenosine triphosphate (DB00171, rank:02)

 
 

Teniposide (DB00444)

Irinotecan (DB00762, rank:04)

T

 

Etoposide (DB00773)

Glutathione (DB00143, rank:07)

 
 

Topotecan (DB01030)

Doxorubicin (DB00997, rank:09)

T

  

Daunorubicin (DB00694, rank:11)

 
  

Sorafenib (DB00398, rank:13)

 
  

Ponatinib (DB08901, rank:16)

 
  

Epirubicin (DB00445, rank:18)

T

  1. In the “Direct Evidence” item, according to the instructions in CTD database, “T” means “therapeutic”, i.e., the drug has a curated association to the disease, other top-ranked drugs aren’t signed with “T” in this table means that they have an inferred association via a curated gene interaction