Skip to main content

Table 4 The top-ranked predictions for selected diseases(Verification in CTD database)

From: Predicting drug-disease interactions by semi-supervised graph cut algorithm and three-layer data integration

Disease Known drugs Part of top-ranked predictions Direct evidence
HD (143100) Baclofen (DB00181) Clozapine (DB00363, rank:01)  
  Tetrabenazine (DB04844) Olanzapine (DB00334, rank:03) T
   Aripiprazole (DB01238, rank:06) T
   Amitriptyline (DB00321, rank:10)  
   Risperidone (DB00734, rank:12)  
NSCLC (211980) Doxorubicin (DB00997) Carboplatin (DB00958, rank:01) T
   Adenosine triphosphate (DB00171, rank:02)  
   Glutathione (DB00143, rank:05)  
   Ponatinib (DB08901, rank:09)  
   Sorafenib (DB00398, rank:10)  
   Dasatinib (DB01254, rank:14)  
   Daunorubicin (DB00694, rank:15)  
   Epirubicin (DB00445, rank:16) T
   Bosutinib (DB06616, rank:18)  
   Caffeine (DB00201, rank:19)  
   Cisplatin (DB00515, rank:20) T
AD (103780) Citalopram (DB00215) Lorazepam (DB00186, rank:04) T
  Chlordiazepoxide (DB00475) Diazepam (DB00829, rank:10)  
  Acamprosate (DB00659) Clomipramine (DB01242, rank:13)  
  Naltrexone (DB00704) Flunitrazepam (DB01544, rank:14)  
  Disulfiram (DB00822) Adenosine triphosphate (DB00171, rank:17)  
  Ondansetron (DB00904) Trazodone (DB00656, rank:18)  
   Imipramine (DB00458, rank:20)  
SCLC (182280) Cisplatin (DB00515) Carboplatin (DB00958, rank:01) T
  Methotrexate (DB00563) Adenosine triphosphate (DB00171, rank:02)  
  Teniposide (DB00444) Irinotecan (DB00762, rank:04) T
  Etoposide (DB00773) Glutathione (DB00143, rank:07)  
  Topotecan (DB01030) Doxorubicin (DB00997, rank:09) T
   Daunorubicin (DB00694, rank:11)  
   Sorafenib (DB00398, rank:13)  
   Ponatinib (DB08901, rank:16)  
   Epirubicin (DB00445, rank:18) T
  1. In the “Direct Evidence” item, according to the instructions in CTD database, “T” means “therapeutic”, i.e., the drug has a curated association to the disease, other top-ranked drugs aren’t signed with “T” in this table means that they have an inferred association via a curated gene interaction