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Table 3 Clinical and demographic information of the patients with infantile spasm

From: Efficient strategy for the molecular diagnosis of intractable early-onset epilepsy using targeted gene sequencing

  Total number Group 1 (Patients with positive genetic cause, % within group 1) Group 2 (Patients without positive genetic cause, % within group 2) P-value
Number of subjects 51 16 35  
Female 23 10 (62.5) 13 (37.1) 0.09
Seizure onset (months)     1.00
 0 < n ≤ 12 months 49 16 (100) 33 (94.3)  
 12 months < n ≤ 24 months 2 0 2 (5.7)  
 24 months < n ≤ 36 months 0 0 0  
 mean age (± standard deviation)   3.2 (± 3.0) 6.2 (± 4.4) 0.02
Global developmental delay 41 14 (87.5) 27 (77.1) 0.47
Absence of eye contact 14 8 (50.0) 6 (17.1) 0.02
Neonatal seizures 9 5 (31.3) 4 (11.4) 0.12
Febrile seizures 2 2 (12.5) 0 0.09
Status epilepticus 1 0 1 (2.9) 1.00
Premature death 2 1 (6.3) 1 (2.9) 0.53
NICU stay 20 7 (43.8) 8 (22.9) 0.19