MAF interval | SNVs whose risk alleles were minor alleles | SNVs whose risk alleles were major alleles | Observed proportiona | Statistical power of detecting minor alleles | Statistical power of detecting major alleles | Expected proportionb | P-valuec (Original) | P-valued (Considering the GWAS’s power imbalance) | Lower limite (Considering the GWAS’s power imbalance) | Upper limite (Considering the GWAS’s power imbalance) |
---|---|---|---|---|---|---|---|---|---|---|
(0, 0.1) | 18 | 0 | 1.0 | 0.002 | 0.001 | 0.67 | 0.0000076*f | 0.0015 *f | 0.81 | 1.00 |
(0.1, 0.2) | 3 | 3 | 0.5 | 0.100 | 0.059 | 0.63 | 1.00 | 0.68 | 0.11 | 0.88 |
(0.2, 0.3) | 2 | 2 | 0.5 | 0.330 | 0.248 | 0.57 | 1.00 | 0.66 | 0.05 | 0.85 |
(0.3, 0.4) | 0 | 2 | 0 | 0.507 | 0.444 | 0.53 | 0.50 | 0.22 | 0.00 | 0.84 |
(0.4, 0.5) | 0 | 1 | 0 | 0.579 | 0.558 | 0.51 | 1.00 | 0.49 | 0.00 | 0.975 |