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Fig. 8 | BMC Medical Genomics

Fig. 8

From: Computational master-regulator search reveals mTOR and PI3K pathways responsible for low sensitivity of NCI-H292 and A427 lung cancer cell lines to cytotoxic action of p53 activator Nutlin-3

Fig. 8

Results of CMA analysis of up-regulated genes in Nutlin-3 insensitive cell lines. a Combination of 14 PWMs with their optimized cut-offs identified by genetic algorithm. b The discriminative parameters of the composition of the Composite Score (p-value of the Wilcoxon test, AUC, rates of false positives and false negatives) and two histograms of the distributions of the Composite Score values in Yes and No promoters. C) An example of the site location in the promoter of MTOR gene. The promoter of MTOR gene contains predicted sites for p53, E2F-1, EGR1 and several other transcription factors

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BMC Medical Genomics

ISSN: 1755-8794

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