Fig. 9

Visualization of the part of signal transduction network that connects identified master-regulators (red) with the transcription factors (blue) found in the promoter analysis of genes upregulated in Nutlin-3 insensitive cell lines. Differential expression of genes encoding the corresponding proteins on the diagram is shown by the color of the layer around the molecule. Yellow color corresponds to increased expression (up-regulation) in Nutlin-3 insensitive cell lines compared to the sensitive cell line. The intensity of the color reflects the fold change