Table 3 Analysis of significantly hypermethylated differentially methylated probes (DMPs)
From: Methylation of the genes ROD1, NLRC5, and HKR1 is associated with aging in Hainan centenarians
GO ID | Description | P Value | Genes |
|---|---|---|---|
Biological process | |||
 GO:0048002 | antigen processing and presentation of peptide antigen | 4.27E-04 | HLA-A, HLA-C, HLA-DRA |
 GO:0019882 | antigen processing and presentation | 3.70E-03 | HLA-A, HLA-C, HLA-DRA |
 GO:0002474 | antigen processing and presentation of peptide antigen via MHC class I | 1.86E-02 | HLA-A, HLA-C |
Cellular component | |||
 GO:0042611 | MHC protein complex | 1.71E-03 | HLA-A, HLA-C, HLA-DRA |
 GO:0042612 | MHC class I protein complex | 3.02E-02 | HLA-A, HLA-C |
 GO:0005626 | insoluble fraction | 5.95E-02 | ELOVL2, HLA-C, CYP2E1, CAPN2 |
 GO:0044459 | plasma membrane part | 7.76E-02 | HLA-A, HLA-C, CACNA1E, TM4SF1, AFAP1, HLA-DRA |
 GO:0005886 | plasma membrane | 8.86E-02 | NRP1, HLA-A, HLA-C, CACNA1E, TM4SF1, CAPN2, AFAP1, HLA-DRA |
 GO:0031224 | intrinsic to membrane | 8.97E-02 | ZPLD1, NRP1, ELOVL2, HLA-A, HLA-C, CACNA1E, TM4SF1, LOC153328, CYP2E1, HLA-DRA |
Molecular function | |||
 GO:0032393 | MHC class I receptor activity | 2.07E-02 | HLA-A, HLA-C |
 GO:0032395 | MHC class II receptor activity | 2.31E-02 | HLA-C, HLA-DRA |