Whole transcriptome analysis reveals differential gene expression profile reflecting macrophage polarization in response to influenza A H5N1 virus infection

Table 1 Fitted expression of macrophage subtype-specific markers

Gene	Subtype	β₀^a	β_subtype	p-value	Gene	Subtype	β₀	β_subtype	p-value
CCL2	M1	− 11.57	1.73	0.005	CCL17	M2a	− 12.04	− 1.04	< 0.001
CCL3	M1	− 9.66	1.18	0.009	CCL18	M2a	− 13.42	− 0.459	0.219
CCL5	M1	− 11.82	2.03	0.034	CCL22	M2a	− 7.24	0.0164	0.904
CXCL10	M1	expressed in H5N1 6-h only			CCL24	M2a	− 13.58	− 1.19	0.066
CXCL11	M1	− 24.95	13.07	0.001	CXCR1	M2a	not expressed
CXCL16	M1	− 8.47	0.0759	0.443	CXCR2	M2a	not expressed
CXCL9	M1	− 13.76	2.25	0.027	IL1R2	M2a	− 11.25	− 0.300	0.027
IL12A	M1	− 13.98	0.576	0.150	CD163	M2a	− 9.96	0.238	0.176
IL23A	M1	− 13.64	0.835	0.148	FCER2	M2a	− 12.21	− 1.28	0.003
IL8	M1	− 8.87	0.881	0.100	IL10	M2a/b/c	− 11.86	0.379	0.035
CCR7	M1	− 11.97	0.367	0.351	ARG1	M2a/b/c	− 14.54	− 0.289	0.652
TLR2	M1	− 9.74	0.288	0.028	IL1RN	M2a/c	− 7.34	0.677	0.002
TLR4	M1	− 8.28	0.488	< 0.001	MRC1	M2a/c	− 12.23	− 0.869	0.182
					MRC2	M2a/c	− 9.79	− 0.455	0.032
					CCL1	M2b	− 13.94	− 0.895	0.098
					CCL16	M2c	− 13.39	− 0.814	0.067
					CCL18	M2c	− 13.42	− 0.459	0.219
					CXCL13	M2c	− 10.44	− 0.739	< 0.001
					TGFB1	M2c	− 9.45	− 0.508	0.047
					CCR2	M2c	− 12.94	− 0.343	0.378
					CD14	M2c	− 8.83	− 0.592	0.003
					SLAMF1	M2c	− 11.22	− 0.166	0.251

ISSN: 1755-8794