Whole transcriptome analysis reveals differential gene expression profile reflecting macrophage polarization in response to influenza A H5N1 virus infection

Table 2 Significantly enriched pathways in response to influenza H5N1 virus infection at 6-h post-infection

	Pathway Name	Gene Count	Enrichment	FDR p-value
upregulated	NOD-like receptor signaling pathway [KEGG]	58	10	0.012
	RIG-I-like receptor signaling pathway [KEGG]	66	18	0.006
	Chemokine receptors bind chemokines [Reactome]	51	12	0.020
	Cytosolic DNA sensing pathway [KEGG]	55	17	0.019
downregulated	Packaging of telomere ends [Reactome]	43	20	0.000
	RNA polymerase I promoter clearance [Reactome]	69	30	0.005
	Viral mRNA translation [Reactome]	82	39	0.009
	RNA polymerase I promoter opening [Reactome]	48	26	0.009
	Ribosome [KEGG]	84	42	0.011
	Insulin synthesis and secretion [Reactome]	126	50	0.011
	Peptide chain elongation [Reactome]	82	38	0.039

ISSN: 1755-8794