Fig. 1
From: Unearthing new genomic markers of drug response by improved measurement of discriminative power
Released GDSC data. a Garnett et al. [9] analysed a slightly different dataset than the one that was later released. In the released dataset, a panel of 130 drugs was tested against 638 cancer cell lines, leading to 47,748 IC50 values (57.6% of all possible drug-cell pairs). For each cell line, 68 cancer genes were sequenced and their mutational status determined, plus three translocations and a microsatellite instability status. b A dataset Dij can be compiled for each drug-gene combination comprising the ni cell responses to the ith drug (in our case, each response as the logarithm base 10 of IC50 in μM units), with xj(k) being a binary variable indicating whether the jth gene is mutated or not in the kth cell line. Next, a p-value was calculated for each drug-gene pair using the MANOVA test. Those pairs with p-values below an adjusted threshold of 0.00840749 were considered statistically significant (396 of the 8637 drug-gene associations)