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Fig. 8 | BMC Medical Genomics

Fig. 8

From: Unearthing new genomic markers of drug response by improved measurement of discriminative power

Fig. 8

Examples of new genomic markers for drugs without previously-proposed known MANOVA markers. (Left) The EWS_FLI1 translocation is found to be the most discriminative marker for the approved drug Gemcitabine (MCC = 0.18 on the test set), which was missed by the MANOVA test (PMANOVA = 0.06). (Right) The mutational status of the NOTCH1 gene is found to be the most discriminative marker for the development drug BI-2536 (MCC = 0.23 on the test set), which was also missed by the MANOVA test (PMANOVA = 0.03)

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