A combined linkage, microarray and exome analysis suggests MAP3K11 as a candidate gene for left ventricular hypertrophy

Table 5 Top association signals from the microarray data under the LVH trait linkage peaks

Outcome	Region	SNP	MAF	Gene	P-value	Q-value
SL	4q26	rs6839953	0.27	TRAM1L1	1.34 × 10⁻⁴	0.47
SL	15q26.2	rs11074275	0.48	MCTP2	4.27 × 10⁻⁴	0.79
SL	20p12.1	rs721243	0.19	ISM1	7.37 × 10⁻⁵	0.15
CV	1p35.1	rs16835131	0.06	SYNC	1.35 × 10⁻⁵	0.35
CV	6q15	rs10944412	0.27	RNGTT	4.60 × 10⁻⁵	0.93
12LS	5p15.2	rs2589661	0.10	ROPN1L	1.26 × 10^− 4	0.46
12LS	20p11.23	rs6106235	0.18	C20orf26	1.69 × 10⁻⁵	0.09
PC1	11q12.2	rs1790325	0.04	FADS1	2.85 × 10⁻⁵	0.08
PC1	20p12.1	rs13036282	0.005	SPTLC3	2.30 × 10⁻⁴	0.63
PC2	6q16.3	rs1475922	0.06	GRIK2	1.64 × 10⁻⁴	0.94
PC2	9p24.1	rs10975939	0.003	KDM4C	4.67 × 10⁻⁴	1.00
PC2	15q11.2	rs8043191	0.03	CYFIP1	5.95 × 10⁻³	0.52
PC2	22q13.33	rs2688089	0.45	C22orf34	7.02 × 10⁻⁵	0.56

SL Sokolow-Lyon, CV Cornell Voltage product, 12LS twelve-lead sum product, PC1 first principal component, PC2 second principal component, MAF minor allele frequency

ISSN: 1755-8794