Skip to main content

Table 1 Characteristics of subjects in the in vivo dataset

From: Impaired type I interferon regulation in the blood transcriptome of recurrent asthma exacerbations

 

Single AETRI

Non-infectious AEs

Multiple AETRIs

 

(N = 41)

(N = 38)

(N = 11)

Exacerbation samples (n)

41

38

27

Baseline samples (n)

147

124

32

Female Gender

28 (68%)

22 (58%)

9 (82%)

White Race

36 (88%)

33 (87%)

10 (91%)

BMI, kg/m2

27.7 [24.5–31.3]

27.8 [24.7–32.0]

34.2 [27.9–38.7]

GERD

8 (20%)

13 (34%)

6 (55%)

Atopy Status

 Atopic

27 (66%)

25 (66%)

8 (73%)

 Non-Atopic

9 (22%)

8 (21%)

1 (9%)

 Unknown

5 (12%)

5 (13%)

2 (18%)

Asthma Severity at the time of Exacerbation

 Mild Persistent

5 (12%)

2 (5%)

0 (0%)

 Moderate Persistent

20 (49%)

16 (42%)

4 (36%)

 Severe Persistent

16 (39%)

20 (53%)

7 (64%)

FEV1 predicted (%)

88 [65–98]

78 [62–87]

62 [45–95]

IgE level, IU/ml

107 [46–224]

117 [53–198]

64 [47–65]

Inhaled CS use

13 (32%)

19 (50%)

10 (91%)

Systemic CS use

15 (37%)

12 (32%)

4 (36%)

Leukotriene receptor antagonist use

15 (37%)

12 (32%)

4 (36%)

Maximum steroid exposure during an exacerbation

 Systemic

13 (32%)

19 (50%)

10 (91%)

 Inhaled

27 (66%)

19 (50%)

1 (9%)

 Other

1 (2%)

0 (0%)

0 (0%)

Bactin-GAPDH 5′ 3′ ratio exacerbation

0.86 [0.77–0.96]

0.84 [0.78–0.95]

0.86 [0.69–0.93]

Bactin-GAPDH 5′ 3′ ratio baseline

0.85 [0.70–0.93]

0.84 [0.73–0.92]

0.85 [0.73–0.92]

Ratio of M:L whole blood exacerbation

0.19 [0.15–0.32]

0.26 [0.15–0.31]

0.24 [0.20–0.33]

Ratio of M:L whole blood baseline

0.17 [0.13–0.22]

0.20 [0.15–0.26]

0.23 [0.21–0.26]

  1. Data are n (%) or median [25–75 interquartile range] unless otherwise specified
  2. Definition of Abbreviations: AETRI asthma exacerbation triggered by respiratory infection, AEs asthma exacerbations, BMI body mass index, GERD gastroesophageal reflux disease, FEV1 forced expiratory volume in 1 s, IgE immunoglobulin E, CS corticosteroids, GAPDH glyceraldehyde-3-phosphate dehydrogenase, M:L monocytes to lymphocytes