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Table 4 Simulation studies of Type I Error estimates for the six different methods

From: Exact association test for small size sequencing data

  EXAT SKAT SKAT.O RC-SKAT Burden
n = 50
α = 0.05 0.050 0.065 0.096 0.047 0.055
α = 0.01 0.011 0.018 0.020 0.008 0.005
α = 0.001 0.002 0.003 0.001 0.001 0.001
n = 100
α = 0.05 0.044 0.062 0.073 0.050 0.055
α = 0.01 0.006 0.010 0.013 0.013 0.006
α = 0.001 0.000 0.001 0.003 0.001 0
n = 200
α = 0.05 0.050 0.051 0.058 0.050 0.044
α = 0.01 0.011 0.010 0.011 0.012 0.009
α = 0.001 0.001 0.001 0.001 0.002 0.000
n = 500
α = 0.05 0.045 0.049 0.047 0.040 0.046
α = 0.01 0.011 0.012 0.009 0.008 0.006
α = 0.001 0.002 0.001 0.000 0.001 0.001