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Table 4 Simulation studies of Type I Error estimates for the six different methods

From: Exact association test for small size sequencing data

 

EXAT

SKAT

SKAT.O

RC-SKAT

Burden

n = 50

α = 0.05

0.050

0.065

0.096

0.047

0.055

α = 0.01

0.011

0.018

0.020

0.008

0.005

α = 0.001

0.002

0.003

0.001

0.001

0.001

n = 100

α = 0.05

0.044

0.062

0.073

0.050

0.055

α = 0.01

0.006

0.010

0.013

0.013

0.006

α = 0.001

0.000

0.001

0.003

0.001

0

n = 200

α = 0.05

0.050

0.051

0.058

0.050

0.044

α = 0.01

0.011

0.010

0.011

0.012

0.009

α = 0.001

0.001

0.001

0.001

0.002

0.000

n = 500

α = 0.05

0.045

0.049

0.047

0.040

0.046

α = 0.01

0.011

0.012

0.009

0.008

0.006

α = 0.001

0.002

0.001

0.000

0.001

0.001