TY - JOUR AU - Lee, Sungyoung AU - Choi, Sungkyoung AU - Qiao, Dandi AU - Cho, Michael AU - Silverman, Edwin K. AU - Park, Taesung AU - Won, Sungho PY - 2018 DA - 2018/04/20 TI - WISARD: workbench for integrated superfast association studies for related datasets JO - BMC Medical Genomics SP - 39 VL - 11 IS - 2 AB - A Mendelian transmission produces phenotypic and genetic relatedness between family members, giving family-based analytical methods an important role in genetic epidemiological studies—from heritability estimations to genetic association analyses. With the advance in genotyping technologies, whole-genome sequence data can be utilized for genetic epidemiological studies, and family-based samples may become more useful for detecting de novo mutations. However, genetic analyses employing family-based samples usually suffer from the complexity of the computational/statistical algorithms, and certain types of family designs, such as incorporating data from extended families, have rarely been used. SN - 1755-8794 UR - https://doi.org/10.1186/s12920-018-0345-y DO - 10.1186/s12920-018-0345-y ID - Lee2018 ER -