Fig. 3

IMPACT Web Portal. a Query page. User could query single gene and variant, or query a list of genes and variants in the query box. The syntax for query genes are listed next to the query box. b Results page. Query genes and variants are matched with the IMPACT database, and returned as results in three levels: Level 1: Approved drugs; Level 2: Investigational therapeutics and Level 3: Pharmacogenetics drugs. The list is sorted by hypergeometric p-value. c Drug/compound page. By clicking the drug/compound in the results page, it will link to the drug/compound page. For each drug/compound page, the top part of the page provides molecular information about the drug/compound, with external link out to PubChem. The middle part of the page provides the list of target genes and variants, and the database sources where these drug-target genes and variants were collected in the IMPACT database. The bottom part of the page provides the list of clinical trials of the drugs/compounds, with link out to ClinicalTrials.gov