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Table 1 Data Sources used in IMPACT Web Portal Database Construction

From: IMPACT web portal: oncology database integrating molecular profiles with actionable therapeutics

Data Source

Description

Reference

OncoKB

Precision oncology knowledge base of 100 drugs and their 476 genes and 3753 variants.

[7]

CPIC

Pharmacogenetic knowledge of drug-gene interactions of 203 drugs.

[12]

MD Anderson Precision Medicine

Contains 416 approved and investigational oncological drugs and their target genes.

[10]

My Cancer Genome

Contains 237 approved and investigational oncological drugs and their target genes.

[8]

Nature Reviews Drug Discovery: A compre-hensive map of molecular drug targets

A comprehensive mapping of 1578 US FDA-approved drugs and their 667 human targets.

[4]

Food and Drug Administration (FDA.gov)

Contains drug labelling of genes and variants for approved drugs.

[11]

The Drug Repurposing Hub

Extensive annotations of drugs and the genes they target for drug repurposing research. The current version contains 5628 compounds targeting 2172 proteins.

[3]

DSigDB

Approved and investigational therapeutics of drug gene signatures collected from PubChem/ChEMBL and kinase inhibition experiments.

[6]

DGIdb

Drug-gene interactions database collected from ten databases and 41 gene categories.

[5]

NCI-MATCH Trial

Drugs and associated target genes used to recruit various cancer patients (ClinicalTrials.gov NCT02465060).

[1, 9]

Tumor Gene Fusion Data Portal

Data base contains 8695 gene fusions detected from the Cancer Genome Atlas RNA-sequencing data.

[17]

ChimerDB

Comprehensive database of 1066 gene fusions encompassing analysis of RNA-sequencing data, PubMed Abstract text mining and manual curations.

[16]