From: IMPACT web portal: oncology database integrating molecular profiles with actionable therapeutics
Data Source | Description | Reference |
---|---|---|
OncoKB | Precision oncology knowledge base of 100 drugs and their 476 genes and 3753 variants. | [7] |
CPIC | Pharmacogenetic knowledge of drug-gene interactions of 203 drugs. | [12] |
MD Anderson Precision Medicine | Contains 416 approved and investigational oncological drugs and their target genes. | [10] |
My Cancer Genome | Contains 237 approved and investigational oncological drugs and their target genes. | [8] |
Nature Reviews Drug Discovery: A compre-hensive map of molecular drug targets | A comprehensive mapping of 1578 US FDA-approved drugs and their 667 human targets. | [4] |
Food and Drug Administration (FDA.gov) | Contains drug labelling of genes and variants for approved drugs. | [11] |
The Drug Repurposing Hub | Extensive annotations of drugs and the genes they target for drug repurposing research. The current version contains 5628 compounds targeting 2172 proteins. | [3] |
DSigDB | Approved and investigational therapeutics of drug gene signatures collected from PubChem/ChEMBL and kinase inhibition experiments. | [6] |
DGIdb | Drug-gene interactions database collected from ten databases and 41 gene categories. | [5] |
NCI-MATCH Trial | Drugs and associated target genes used to recruit various cancer patients (ClinicalTrials.gov NCT02465060). | |
Tumor Gene Fusion Data Portal | Data base contains 8695 gene fusions detected from the Cancer Genome Atlas RNA-sequencing data. | [17] |
ChimerDB | Comprehensive database of 1066 gene fusions encompassing analysis of RNA-sequencing data, PubMed Abstract text mining and manual curations. | [16] |