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Fig. 1 | BMC Medical Genomics

Fig. 1

From: Performance of in silico prediction tools for the classification of rare BRCA1/2 missense variants in clinical diagnostics

Fig. 1

Multifactorial probability model and determination of Product of LRs thresholds for classification irrespective of Align-GVGD. Visualization of the multifactorial probability model for classification of VUS in BRCA1/2 based on the Posterior P thresholds proposed by Plon et al. [22]. Variants with Products of LRs below or above the corresponding thresholds (indicated with filled circles) were classified independent of the prior probabilities Prior P (based on Align-GVGD predictions) and included in the Evaluation Variant Set and the Classified Variant Set. Variants depicted by unfilled circles were included in the Classified Variant Set exclusively. Classification of these variants was not independent of prior probabilities

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BMC Medical Genomics

ISSN: 1755-8794

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