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Table 2 Common differentially expressed genes identified from blood in PD patients and healthy controls and that PD-specific and other neurodegenerative diseases related genes identification

From: A meta-analysis of public microarray data identifies biological regulatory networks in Parkinson’s disease

Expression Gene symbol Gene name Corresponding neurodegenerative disease other than PD
Down-regulated ABCA1a ATP binding cassette subfamily A member 1 Alzheimer’s disease
ABHD5 abhydrolase domain containing 5  
ADGRG3 adhesion G protein-coupled receptor G3  
AKAP13a A-kinase anchoring protein 13 Alzheimer’s disease
APMAPa adipocyte plasma membrane associated protein Multiple sclerosis; Alzheimer’s disease
ARG1 arginase 1  
BAZ1Aa bromodomain adjacent to zinc finger domain 1A Huntington disease
BMXa BMX non-receptor tyrosine kinase Alzheimer’s disease
CDKL5a cyclin dependent kinase like 5  
CEBPDa CCAAT/enhancer binding protein delta Alzheimer’s disease
CSF2RAa colony stimulating factor 2 receptor alpha subunit Alzheimer’s disease
CTBP2a C-terminal binding protein 2 Alzheimer’s disease
FAM120Aa family with sequence similarity 120A Multiple sclerosis
HLA-Ca major histocompatibility complex, class I, C Multiple sclerosis
HSPA6b heat shock protein family A (Hsp70) member 6  
IRS2 insulin receptor substrate 2  
LILRB1 leukocyte immunoglobulin like receptor B1  
LRRFIP1a LRR binding FLII interacting protein 1 Multiple sclerosis; Huntington disease
MAP2K6b mitogen-activated protein kinase kinase 6  
MAP2K7 mitogen-activated protein kinase kinase 7  
MGAM maltase-glucoamylase  
NCAM1 neural cell adhesion molecule 1  
NCOA3 nuclear receptor coactivator 3  
PMLa promyelocytic leukemia Polyglutamine diseases
SRPK2b SRSF protein kinase 2  
SUPT20Ha SPT20 homolog, SAGA complex component Cerebellar Purkinje cell degeneration
THOC2a THO complex 2 Multiple sclerosis
TMX4a thioredoxin related transmembrane protein 4 Motor neuron disease
Up-regulated ATM ATM serine/threonine kinase  
BCL2a BCL2, apoptosis regulator Alzheimer’s disease
FAM102Aa family with sequence similarity 102 member A Neurodegenerative disease
LRRN3 leucine rich repeat neuronal 3  
NOL7b nucleolar protein 7  
TCF3 transcription factor 3  
TP73-AS1 TP73 antisense RNA 1  
YME1L1a YME1 like 1 ATPase Alzheimer’s disease
  1. aPreviously associated with several neurodegenerative diseases (identified using GCBI online software), but not PD
  2. bPreviously associated with PD (identified using GCBI online software)