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Table 2 Common differentially expressed genes identified from blood in PD patients and healthy controls and that PD-specific and other neurodegenerative diseases related genes identification

From: A meta-analysis of public microarray data identifies biological regulatory networks in Parkinson’s disease

Expression

Gene symbol

Gene name

Corresponding neurodegenerative disease other than PD

Down-regulated

ABCA1a

ATP binding cassette subfamily A member 1

Alzheimer’s disease

ABHD5

abhydrolase domain containing 5

 

ADGRG3

adhesion G protein-coupled receptor G3

 

AKAP13a

A-kinase anchoring protein 13

Alzheimer’s disease

APMAPa

adipocyte plasma membrane associated protein

Multiple sclerosis; Alzheimer’s disease

ARG1

arginase 1

 

BAZ1Aa

bromodomain adjacent to zinc finger domain 1A

Huntington disease

BMXa

BMX non-receptor tyrosine kinase

Alzheimer’s disease

CDKL5a

cyclin dependent kinase like 5

 

CEBPDa

CCAAT/enhancer binding protein delta

Alzheimer’s disease

CSF2RAa

colony stimulating factor 2 receptor alpha subunit

Alzheimer’s disease

CTBP2a

C-terminal binding protein 2

Alzheimer’s disease

FAM120Aa

family with sequence similarity 120A

Multiple sclerosis

HLA-Ca

major histocompatibility complex, class I, C

Multiple sclerosis

HSPA6b

heat shock protein family A (Hsp70) member 6

 

IRS2

insulin receptor substrate 2

 

LILRB1

leukocyte immunoglobulin like receptor B1

 

LRRFIP1a

LRR binding FLII interacting protein 1

Multiple sclerosis; Huntington disease

MAP2K6b

mitogen-activated protein kinase kinase 6

 

MAP2K7

mitogen-activated protein kinase kinase 7

 

MGAM

maltase-glucoamylase

 

NCAM1

neural cell adhesion molecule 1

 

NCOA3

nuclear receptor coactivator 3

 

PMLa

promyelocytic leukemia

Polyglutamine diseases

SRPK2b

SRSF protein kinase 2

 

SUPT20Ha

SPT20 homolog, SAGA complex component

Cerebellar Purkinje cell degeneration

THOC2a

THO complex 2

Multiple sclerosis

TMX4a

thioredoxin related transmembrane protein 4

Motor neuron disease

Up-regulated

ATM

ATM serine/threonine kinase

 

BCL2a

BCL2, apoptosis regulator

Alzheimer’s disease

FAM102Aa

family with sequence similarity 102 member A

Neurodegenerative disease

LRRN3

leucine rich repeat neuronal 3

 

NOL7b

nucleolar protein 7

 

TCF3

transcription factor 3

 

TP73-AS1

TP73 antisense RNA 1

 

YME1L1a

YME1 like 1 ATPase

Alzheimer’s disease

  1. aPreviously associated with several neurodegenerative diseases (identified using GCBI online software), but not PD
  2. bPreviously associated with PD (identified using GCBI online software)