Table 3 Common differentially expressed genes identified from substantia nigra in PD patients and healthy controls, and PD-specific and other neurodegenerative diseases related genes identification

Down-regulated

CARHSP1^a

calcium regulated heat stable protein 1

Multiple sclerosis

GART^a

phosphoribosylglycinamide formyltransferase phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase

Alzheimer’s disease

MUC4

mucin 4, cell surface associated

NIN

ninein

NRF1^a

nuclear respiratory factor 1

Alzheimer’s disease

PRELP^a

proline and arginine rich end leucine rich repeat protein

Nervous system disease; Neurodegenerative disease

RGS12

regulator of G-protein signaling 12

RNF130^a

ring finger protein 130

Motor neuron disease

SNAP23^a

synaptosome associated protein 23

Nervous system disease

SNTB2

syntrophin beta 2

TBX1

T-box 1

Up-regulated

ACSL6^a

acyl-CoA synthetase long-chain family member 6

Nervous system disease

ATP5S^a

ATP synthase, H+ transporting, mitochondrial Fo complex subunit s (factor B)

Alzheimer’s disease

CADPS

calcium dependent secretion activator

DCLK1^a

doublecortin like kinase 1

Alzheimer’s disease

PPFIA2

PTPRF interacting protein alpha 2

SNCA^b

synuclein alpha