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Table 3 Common differentially expressed genes identified from substantia nigra in PD patients and healthy controls, and PD-specific and other neurodegenerative diseases related genes identification

From: A meta-analysis of public microarray data identifies biological regulatory networks in Parkinson’s disease

Expression Gene symbol Gene name Corresponding neurodegenerative disease other than PD
Down-regulated CARHSP1a calcium regulated heat stable protein 1 Multiple sclerosis
GARTa phosphoribosylglycinamide formyltransferase phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase Alzheimer’s disease
MUC4 mucin 4, cell surface associated  
NIN ninein  
NRF1a nuclear respiratory factor 1 Alzheimer’s disease
PRELPa proline and arginine rich end leucine rich repeat protein Nervous system disease; Neurodegenerative disease
RGS12 regulator of G-protein signaling 12  
RNF130a ring finger protein 130 Motor neuron disease
SNAP23a synaptosome associated protein 23 Nervous system disease
SNTB2 syntrophin beta 2  
TBX1 T-box 1  
Up-regulated ACSL6a acyl-CoA synthetase long-chain family member 6 Nervous system disease
ATP5Sa ATP synthase, H+ transporting, mitochondrial Fo complex subunit s (factor B) Alzheimer’s disease
CADPS calcium dependent secretion activator  
DCLK1a doublecortin like kinase 1 Alzheimer’s disease
PPFIA2 PTPRF interacting protein alpha 2  
SNCAb synuclein alpha  
  1. aPreviously associated with several neurodegenerative diseases, other than PD (identified using GCBI online software)
  2. bPreviously associated with PD (PD-specific) (identified using GCBI online software)