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Table 1 Characteristics of African Americans from the GENOA study with cognitive and DNA methylation dataa

From: DNA methylation in the APOE genomic region is associated with cognitive function in African Americans

  Full analysis sampleb Subset samplec
(N = 289) (N = 247)
Age (years) 67.2 (7.1) 67.4 (6.8)
Sex (female) 207 (72%) 183 (74%)
Education Less than high school degree 95 (33%) 83 (34%)
High school degree / GED 81 (28%) 68 (27%)
Beyond high school degree 113 (39%) 96 (39%)
Body mass index (BMI, kg/m2) 30.9 (6.0) 30.9 (6.1)
Current smoker 34 (12%) 29 (12%)
Diabetes 85 (29%) 70 (28%)
Hypertension 241 (83%) 205 (83%)
White matter hyperintensity (WMH, cm3) 12.0 (14.2) 11.9 (13.6)
APOE ε4 carrier N/A 102 (41%)
APOE ε2 carrier N/A 60 (24%)
Processing speed (DSST, symbols)d 30.6 (13.2) 30.4 (13.2)
Category fluency (Animal Naming, words)d 14.2 (4.4) 14.0 (4.2)
Letter fluency (FAS, words)d 28.2 (11.5) 28.1 (11.5)
Learning (RAVLT, words)d 38. 5 (9.7) 38.5 (9.5)
Delayed recall (RAVLT, words)d 6.1 (3.6) 6.2 (3.6)
Concentration effectiveness (SCWT, items)d 20.5 (9.1) 20.4 (8.9)
Global cognitive function − 0.12 (0.95) − 0.17 (0.94)
  1. aMean (standard deviation) or n (%) are presented
  2. bIn the full sample, sample sizes for the cognitive measures range from 243 to 289. A total of 232 participants had data for WMH
  3. cSubset sample consists of subjects with available genotype data
  4. dValues of cognitive scores are the numbers of symbols, words, or items completed within certain time limits as required by each test. For additional details, see Smith et al. [19]