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Table 2 Association between DNA methylation and delayed recall for significant CpGs in the full analysis sample (N = 282)a

From: DNA methylation in the APOE genomic region is associated with cognitive function in African Americans

  PVRL2 TOMM40 APOE
  cg26717215 cg08583001 cg11670000 cg22024783 cg12271581 cg04406254 cg01032398 cg18768621
Region feature(s)b Promoter, CGI Promoter, CGI CGI shelf Promoter, CGI Promoter, CGI Promoter, CGI shelf Promoter, CGI shelf CGI shelf
  β (q) R2 β (q) ∆R 2 β (q) R2 β (q) R2 β (q) R2 β (q) R2 β (q) R2 β (q) R2
Model 1c −0.66
(0.048)
0.03 − 0.37
(0.086)
0.02 − 0.20
(0.086)
0.02 −0.40
(0.086)
0.02 −0.43
(0.086)
0.02 −0.23
(0.086)
0.02 −0.38
(0.012)
0.04 −0.32
(0.048)
0.03
Model 2d −0.62
(0.058)
0.03 −0.42
(0.058)
0.03 −0.19
(0.120)
0.02 −0.41
(0.086)
0.02 −0.39
(0.121)
0.02 −0.23
(0.086)
0.02 −0.35
(0.026)
0.03 −0.29
(0.058)
0.02
  1. aIn the full sample, 282 participants had non-missing delayed recall measures. Only CpG sites that had a significant association with delayed recall (FDR q < 0.1) after adjustment for age and sex (Model 1) are shown. β (q) represents the estimated change in delayed recall score for a 1% increase in methylation level of the CpG site, after adjustment for model covariates, and its associated q-value. ∆R2 is the additional percent variation in delayed recall explained by the CpG site in the model, compared to the reduced model with only covariates
  2. bRegion feature(s) are from Illumina annotation. “Promoter” = within 1.5 kb before the transcription start site of a gene; “CGI” = within a CpG island; “CGI shelf” = 2-4 kb from CGI
  3. cModel 1: Delayed recall = CpG methylation + age + sex
  4. dModel 2: Delayed recall = CpG methylation + age + sex + education