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Table 2 Association between DNA methylation and delayed recall for significant CpGs in the full analysis sample (N = 282)a

From: DNA methylation in the APOE genomic region is associated with cognitive function in African Americans

 

PVRL2

TOMM40

APOE

 

cg26717215

cg08583001

cg11670000

cg22024783

cg12271581

cg04406254

cg01032398

cg18768621

Region feature(s)b

Promoter, CGI

Promoter, CGI

CGI shelf

Promoter, CGI

Promoter, CGI

Promoter, CGI shelf

Promoter, CGI shelf

CGI shelf

 

β (q)

R2

β (q)

∆R 2

β (q)

R2

β (q)

R2

β (q)

R2

β (q)

R2

β (q)

R2

β (q)

R2

Model 1c

−0.66

(0.048)

0.03

− 0.37

(0.086)

0.02

− 0.20

(0.086)

0.02

−0.40

(0.086)

0.02

−0.43

(0.086)

0.02

−0.23

(0.086)

0.02

−0.38

(0.012)

0.04

−0.32

(0.048)

0.03

Model 2d

−0.62

(0.058)

0.03

−0.42

(0.058)

0.03

−0.19

(0.120)

0.02

−0.41

(0.086)

0.02

−0.39

(0.121)

0.02

−0.23

(0.086)

0.02

−0.35

(0.026)

0.03

−0.29

(0.058)

0.02

  1. aIn the full sample, 282 participants had non-missing delayed recall measures. Only CpG sites that had a significant association with delayed recall (FDR q < 0.1) after adjustment for age and sex (Model 1) are shown. β (q) represents the estimated change in delayed recall score for a 1% increase in methylation level of the CpG site, after adjustment for model covariates, and its associated q-value. ∆R2 is the additional percent variation in delayed recall explained by the CpG site in the model, compared to the reduced model with only covariates
  2. bRegion feature(s) are from Illumina annotation. “Promoter” = within 1.5 kb before the transcription start site of a gene; “CGI” = within a CpG island; “CGI shelf” = 2-4 kb from CGI
  3. cModel 1: Delayed recall = CpG methylation + age + sex
  4. dModel 2: Delayed recall = CpG methylation + age + sex + education