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Table 1 The demographic information of participants with plasma NFL data

From: Genome-wide association study identifies two loci influencing plasma neurofilament light levels

Baseline diagnosis AD MCI HC Total
n 172 176 179 527
Age (years), mean ± SD (range) 76 ± 7 (56–91) 75 ± 8 (54–89) 76 ± 5 (62–90) 75 ± 7 (54–91)
Gender, male/female 90/82 117/59 103/76 310/217
APOE ε4 carrier (%) 66.9 52.8 26.8 48.6
Plasma NFL (pg/ml), mean ± SDa 48.7 ± 20.9 39.9 ± 17.7 32.8 ± 15.5 40.4 ± 19.3
  1. Abbreviations: AD Alzheimer’s disease, APOE Apolipoprotein E; HC healthy control, MCI mild cognitive impairment, NFL neurofilament light, SD standard deviation
  2. aPlasma NFL levels were different across the 3 diagnostic groups (P < 0.0001). Tukey’s multiple comparisons test showed that AD patients had higher plasma NFL levels compared with MCI group and healthy controls (P < 0.001). MCI group also had higher plasma NFL levels compared to healthy controls (P = 0.0007)