Genome-wide association study identifies two loci influencing plasma neurofilament light levels

BMC Medical Genomics

Table 1 The demographic information of participants with plasma NFL data

Baseline diagnosis	AD	MCI	HC	Total
n	172	176	179	527
Age (years), mean ± SD (range)	76 ± 7 (56–91)	75 ± 8 (54–89)	76 ± 5 (62–90)	75 ± 7 (54–91)
Gender, male/female	90/82	117/59	103/76	310/217
APOE ε4 carrier (%)	66.9	52.8	26.8	48.6
Plasma NFL (pg/ml), mean ± SD^a	48.7 ± 20.9	39.9 ± 17.7	32.8 ± 15.5	40.4 ± 19.3

Abbreviations: AD Alzheimer’s disease, APOE Apolipoprotein E; HC healthy control, MCI mild cognitive impairment, NFL neurofilament light, SD standard deviation
^aPlasma NFL levels were different across the 3 diagnostic groups (P < 0.0001). Tukey’s multiple comparisons test showed that AD patients had higher plasma NFL levels compared with MCI group and healthy controls (P < 0.001). MCI group also had higher plasma NFL levels compared to healthy controls (P = 0.0007)

ISSN: 1755-8794