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Table 3 CARE hierarchical clustering results

From: African ancestry is associated with cluster-based childhood asthma subphenotypes

  Cluster 1 (N = 60) Cluster 2 (N = 129) Cluster 3 (N = 209) p-value
Age (years) 10.1 (2.4) 10.1 (2.5) 11.0 (3.1) 0.0124
Gender No. (%)     0.1185
 Male 30 (50) 77 (59.7) 135 (64.6)  
 Female 30 (50) 52 (40.3) 74 (35.4)  
Race No. (%)     0.4519
 Caucasian 40 (66.7) 67 (51.9) 108 (51.7)  
 African American 8 (13.3) 24 (18.6) 38 (18.2)  
 Hispanic 8 (13.3) 24 (18.6) 46 (22.0)  
 Other 4 (6.7) 14 (10.9) 17 (8.1)  
BMIZ 0.9 (0.9) 0.8 (1.0) 0.8 (1.0) 0.5920
Age of onset (years) 3.6 (3.5) 3.1 (2.6) 4.1 (3.5) 0.0215
FEV1 PC20 meth (mg/ml) 3.3 (3.3) 1.6 (2.4) 2.3 (3.4) 0.0031
FEV1 percent predicted 97.2 (13.4) 96.3 (13.1) 97.6 (12.5) 0.655
FVC percent predicted 104.7 (10.7) 107.2 (12.5) 106.9 (12.3) 0.378
FEV1/FVC ratio 81.6 (8.5) 79.0 (8.0) 80.4 (7.9) 0.101
Bronchodilator percent change 6.7 (7.4) 9.9 (7.4) 9.8 (9.0) 0.0271
Blood eosinophils (mm3) 245.7 (211.5) 444.4 (322.1) 435.0 (330.2) < 0.0001
IgE (ng/ml) 63.5 (133.9) 424.5 (537.1) 347.4 (430.1) < 0.0001
Average AM peak flow (L/min) 255.4 (68.7) 258.6 (81.0) 283.3 (102.3) 0.0209
Average AM symptoms 0.43 (0.32) 0.50 (0.40) 0.53 (0.42) 0.202
Environmental smoke No. (%) 28 (46.7) 62 (48.1) 104 (49.8) 0.8985
In utero smoke No. (%) 1 (1.7) 18 (14.0) 35 (16.9) 0.0121
Atopic dermatitis No. (%) 21 (35) 127 (98.4) 7 (3.3) < 0.0001
Positive SPT No. (%) 0 (0) 123 (95.3) 189 (92.2) < 0.0001
  1. Mean and SD for continuous variables and No. (%) for categorical variables