Table 3 CARE hierarchical clustering results
From: African ancestry is associated with cluster-based childhood asthma subphenotypes
| Cluster 1 (N = 60) | Cluster 2 (N = 129) | Cluster 3 (N = 209) | p-value | |
|---|---|---|---|---|
| Age (years) | 10.1 (2.4) | 10.1 (2.5) | 11.0 (3.1) | 0.0124 |
| Gender No. (%) | 0.1185 | |||
| Male | 30 (50) | 77 (59.7) | 135 (64.6) | |
| Female | 30 (50) | 52 (40.3) | 74 (35.4) | |
| Race No. (%) | 0.4519 | |||
| Caucasian | 40 (66.7) | 67 (51.9) | 108 (51.7) | |
| African American | 8 (13.3) | 24 (18.6) | 38 (18.2) | |
| Hispanic | 8 (13.3) | 24 (18.6) | 46 (22.0) | |
| Other | 4 (6.7) | 14 (10.9) | 17 (8.1) | |
| BMIZ | 0.9 (0.9) | 0.8 (1.0) | 0.8 (1.0) | 0.5920 |
| Age of onset (years) | 3.6 (3.5) | 3.1 (2.6) | 4.1 (3.5) | 0.0215 |
| FEV1 PC20 meth (mg/ml) | 3.3 (3.3) | 1.6 (2.4) | 2.3 (3.4) | 0.0031 |
| FEV1 percent predicted | 97.2 (13.4) | 96.3 (13.1) | 97.6 (12.5) | 0.655 |
| FVC percent predicted | 104.7 (10.7) | 107.2 (12.5) | 106.9 (12.3) | 0.378 |
| FEV1/FVC ratio | 81.6 (8.5) | 79.0 (8.0) | 80.4 (7.9) | 0.101 |
| Bronchodilator percent change | 6.7 (7.4) | 9.9 (7.4) | 9.8 (9.0) | 0.0271 |
| Blood eosinophils (mm3) | 245.7 (211.5) | 444.4 (322.1) | 435.0 (330.2) | < 0.0001 |
| IgE (ng/ml) | 63.5 (133.9) | 424.5 (537.1) | 347.4 (430.1) | < 0.0001 |
| Average AM peak flow (L/min) | 255.4 (68.7) | 258.6 (81.0) | 283.3 (102.3) | 0.0209 |
| Average AM symptoms | 0.43 (0.32) | 0.50 (0.40) | 0.53 (0.42) | 0.202 |
| Environmental smoke No. (%) | 28 (46.7) | 62 (48.1) | 104 (49.8) | 0.8985 |
| In utero smoke No. (%) | 1 (1.7) | 18 (14.0) | 35 (16.9) | 0.0121 |
| Atopic dermatitis No. (%) | 21 (35) | 127 (98.4) | 7 (3.3) | < 0.0001 |
| Positive SPT No. (%) | 0 (0) | 123 (95.3) | 189 (92.2) | < 0.0001 |