Fig. 4From: RNA sequencing-based longitudinal transcriptomic profiling gives novel insights into the disease mechanism of generalized pustular psoriasisRegulatory network analysis. a Upstream Regulator Analysis. The top 20 upstream regulators associated with cytokine pathways (ranked by average z-score) are presented as a bar chart. The z-score is used to predict the activation state of a putative regulator (either activated or inhibited). b Regulatory Effects Analysis. The Regulatory Effects network was generated by connections between predicted upstream regulators, DEGs, and predicted downstream functions or diseases. The network with the highest consistency score is presentedBack to article page