Table 2 Differential expressed genes in involved in neutrophil function
Process | Gene Symbol |
|---|---|
Development | CSF3R |
Protein trafficking | CD63, AP3S1, AP3M2, AP1S3, AP1B1, AP1G2, AP1G1, AP2M1 |
Granule formation | MMP9, LTF, LCN2, HP, MMP8, DEFA1, DEFA4, ELANE, PRTN3, AZU1 |
Capture and rolling | PTX3 |
Arrest | ITGB2, CD44 |
Activation during transmigration | PIK3R5, MAPK14 |
Pattern recognition, migration | FPR1, FPR2, IFNGR1, LTB4R, TLR1, TLR5, MYD88, IRAK4, CLEC7A, NLRP3, NLRC4 |
Cytokine secretion | IL1B, IL8 |
Immune crosstalk | TNFSF13B, ARG1 |
phagocytosis and degranulation | NCF1, HCK, PTK2, RAB27A, RAB27B |
Pyroptosis, autophagy | ATG3, GABARAPL1, CASP1 |
Apoptosis | HTRA2, CASP3 |