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Table 2 Genes differentially expressed between responders and non-responders to HCTZ and chlorthalidone in all 3 cohorts, with consistent direction and transcriptome-wide statistical significance when meta-analyzed

From: Blood pressure signature genes and blood pressure response to thiazide diuretics: results from the PEAR and PEAR-2 studies

 

HCTZ Whites

Chlorthalidone Whites

Chlorthalidone Blacks

Meta-analysis

Genes

Non-resp.

Resp.

Fold Change

P value

Non-resp.

Resp.

Fold Change

P value

Non-resp.

Resp.

Fold Change

P value

P value

FOS

39.2

49.5

1.26

2.90E-03

29.4

38.0

1.29

1.15E-03

24.6

35.9

1.46

5.00E-05

2.08E-12

DUSP1

76.0

105.2

1.38

1.50E-04

71.5

92.8

1.30

1.35E-03

63.3

81.7

1.29

3.55E-03

9.50E-12

PPP1R15A

38.3

48.7

1.27

1.15E-03

29.9

35.5

1.19

3.61E-02

27.6

35.6

1.29

1.75E-03

3.64E-08

  1. Fold change corresponds to gene expression levels in responders divided by levels in non-responders, in fragments per kilobase per million reads (FPKM)