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Table 2 Genes differentially expressed between responders and non-responders to HCTZ and chlorthalidone in all 3 cohorts, with consistent direction and transcriptome-wide statistical significance when meta-analyzed

From: Blood pressure signature genes and blood pressure response to thiazide diuretics: results from the PEAR and PEAR-2 studies

  HCTZ Whites Chlorthalidone Whites Chlorthalidone Blacks Meta-analysis
Genes Non-resp. Resp. Fold Change P value Non-resp. Resp. Fold Change P value Non-resp. Resp. Fold Change P value P value
FOS 39.2 49.5 1.26 2.90E-03 29.4 38.0 1.29 1.15E-03 24.6 35.9 1.46 5.00E-05 2.08E-12
DUSP1 76.0 105.2 1.38 1.50E-04 71.5 92.8 1.30 1.35E-03 63.3 81.7 1.29 3.55E-03 9.50E-12
PPP1R15A 38.3 48.7 1.27 1.15E-03 29.9 35.5 1.19 3.61E-02 27.6 35.6 1.29 1.75E-03 3.64E-08
  1. Fold change corresponds to gene expression levels in responders divided by levels in non-responders, in fragments per kilobase per million reads (FPKM)