Fig. 5From: Calculating the statistical significance of rare variants causal for Mendelian and complex disordersHistogram of the number of individuals with rare LOF variants in putative autism genes. The distribution of the number of individuals with a rare variant (MAF < 0.1%) in all genes is nearly identical to the distribution for putative autism genes (N = 1145) and high-confidence autism genes (N = 109) (dashed lines), suggesting that the genes may have been associated with autism by chance. Genes that frequently contain rare LOF variants in the population (red shaded region) are unlikely to be causal for ASDBack to article page