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Fig. 1 | BMC Medical Genomics

Fig. 1

From: Genetic interaction effects reveal lipid-metabolic and inflammatory pathways underlying common metabolic disease risks

Fig. 1

Association test results for type 2 diabetes. Dotted horizontal lines represent the Bonferroni threshold. a Non-interacting single-nucleotide polymorphisms (SNPs). b Pathways with (collective loci inference; CL) and without interaction effects (independent loci; IL) with varying numbers of SNPs in each group, scored with the cross-validation prediction measure, the area under the curve (AUC). Red symbols represent those with a false discovery rate (FDR) below 0.05. c Regression of p-values against the AUC (dotted line: fit to quadratic orthogonal polynomial). d, e Top-ranked pathways organized into the Reactome hierarchy (dendrograms). activ., activates/activation/activated; biosynth., biosynthesis; cont., containing; cytoch., cytochrome; deactiv., deactivation; degrad., degradation; dep., dependent; downstr., downstream; DSB, double-strand break; elong., elongation; eukar., eukaryotic; expr., expression; FGFR, fibroblast growth factor R.; form., formation; GLP, glucagon-like peptide; GPCR, G protein-coupled R.; HDR, homology-directed repair; HR, homologous recombination; HRR, HR repair; hydrol., hydrolysis; inactiv., inactivation; ind., induced; init., initiation; inter., interaction; K+, potassium; med., mediated; metab., metabolism; mito., mitochondria; path., pathway; PCD, programmed cell death; phosphoryl., phosphorylation; pol, polymerase; proc., processing; prot., protein; R., receptor; recog., recognition; reg., regulates; repl., replicative; repress., repression; resp., response; SALM, synaptic adhesion-like molecule; secret., secretion; sig., signaling; sol., soluble; SSA, single-strand annealing; synth., synthesis; term., termination; thru, through; transcr., transcription; transl., translation; transloc., translocation; transp., transport; UPR, unfolded protein response

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