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Fig. 5 | BMC Medical Genomics

Fig. 5

From: Genetic interaction effects reveal lipid-metabolic and inflammatory pathways underlying common metabolic disease risks

Fig. 5

Association test results for coronary artery disease. Horizontal lines represent the Bonferroni threshold. a Non-interacting SNPs. b Pathways with (CL) and without (IL) interaction effects. Red symbols indicate pathways with an FDR below 0.05. c Regression of p-values against the AUC. df Top-ranked pathways with AUC > 0.53. Ag., antigen; biogen., biogenesis; biol., biology; cell., cellular; comm., communication; conv., conversion; devel., developmental; ECM, extracellular matrix; ER, endoplasmic reticulum; FA, fatty acid; IFN, interferon; IL, interleukin; maint., maintenance; MHC, major histocompatibility complex; NCAM, neural cell adhesion molecule; NMDAR, n-methyl d-aspartate receptor; ox., oxidative; PPARA, peroxisome proliferator-activated receptor alpha; present., presentation; rxn., reaction; SCF, stem cell factor; surf., surface; TAR, triacylglyceride; TF, transcription factor; TLR, Toll-like receptors; transl., translation; VEGF, vascular endothelial growth factor

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