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Fig. 6 | BMC Medical Genomics

Fig. 6

From: Genetic interaction effects reveal lipid-metabolic and inflammatory pathways underlying common metabolic disease risks

Fig. 6

Association test results for hypertension. a Non-interacting SNPs. b Pathways with (CL) and without (IL) interaction effects. Red symbols indicate pathways with an FDR below 0.05. c Regression of p-values against the AUC. d, e Top-ranked pathways with AUC > 0.53. 5-HETE, 5-hydroxy-eicosatetraenoic acid; AMPK, AMP-activated kinase; assoc., association; checkpt., checkpoint; conv., conversion; COPII, coat protein 2; degranul., degranulation; downreg., downregulation; EGFR, epidermal growth factor receptor; fragment., fragmentation; func., function; GABA, gamma-aminobutyric acid; GIP, glucose-dependent insulinotropic polypeptide; indep., independent; inhib., inhibition; mod., modification; mTOR, target of rapamycin; org., organization; presynap., presynaptic; proteol., proteolytic; recomb., recombination; reorg., reorganization; transactiv., transactivation; TRiC/CCT, TCP1-ring complex or chaperonin containing TCP1

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