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Table 4 Association of previously reported T2D loci with risk of GDM according to both criteria

From: Association between genetic risk variants and glucose intolerance during pregnancy in north Indian women

SNP EA Chr Gene/nearest gene Location WHO 1999 WHO 2013 n
OR CI(lower) CI(upper) p-value OR CI(lower) CI(upper) p-value
rs2296172 G 1 MACF1 coding-missense 0.92 0.71 1.20 0.56 1.04 0.89 1.21 0.58 3847
rs340874 C 1 PROX1 intergenic 0.94 0.80 1.11 0.52 0.96 0.87 1.06 0.47 3709
rs7578597 T 2 THADA coding-missense 0.90 0.72 1.12 0.37 0.92 0.80 1.06 0.27 3710
rs243088 T 2 BCL 11A intergenic 1.10 0.94 1.29 0.22 1.07 0.97 1.18 0.15 3717
rs7593730 T 2 RBMS1/ITGB6 intronic 1.01 0.84 1.22 0.83 0.99 0.88 1.11 0.93 3906
rs7607980 C 2 COBLL1 coding-missense 0.95 0.73 1.24 0.75 0.95 0.81 1.11 0.52 3885
rs13389219 C 2 GRB14 intergenic 1.25 1.03 1.52 0.022 1.11 0.99 1.23 0.058 3829
rs7578326 A 2 KIAA1486/IRS1 intron of uncharacterized LOC646736 0.97 0.80 1.18 0.78 0.98 0.87 1.10 0.79 3600
rs2943641 C 2 IRS1 intergenic 0.92 0.76 1.12 0.43 0.97 0.87 1.09 0.67 3643
rs4675095 A 2 IRS1 intron 1.11 0.87 1.42 0.39 1.04 0.90 1.19 0.58 3817
rs831571 C 3 PSMD6 intergenic 1.02 0.84 1.25 0.77 0.93 0.83 1.05 0.26 3726
rs4607103 C 3 ADAMTS9-AS2 intron 1.14 0.98 1.33 0.08 1.00 0.91 1.09 0.97 3884
rs11920090 T 3 SLC2A2 intron 1.19 0.93 1.51 0.16 1.16 1.01 1.33 0.03 3606
rs6815464 C 4 MAEA intron 1.04 0.83 1.30 0.71 1.03 0.90 1.18 0.64 3722
rs459193 G 5 ANKRD55 intergenic 0.99 0.84 1.16 0.90 1.07 0.97 1.18 0.16 3884
rs4457053 G 5 ZBED3 intron of ZBED3-AS1 1.05 0.86 1.29 0.57 0.95 0.84 1.07 0.45 3579
rs9470794 C 6 ZFAND3 intron 1.07 0.85 1.35 0.51 1.05 0.91 1.21 0.48 3608
rs17168486 T 7 DGKB intergenic 0.99 0.83 1.17 0.92 0.97 0.88 1.07 0.62 3855
rs2191349 T 7 DGKB/TMEM195 intergenic 1.04 0.88 1.22 0.62 1.00 0.91 1.10 0.95 3903
rs864745 T 7 JAZF1 intron 0.98 0.83 1.16 0.87 1.02 0.92 1.13 0.68 3876
rs4607517 A 7 GCK intergenic 1.04 0.82 1.32 0.70 1.01 0.88 1.16 0.86 3903
rs17133918 C 7 GRB10 intron 1.03 0.87 1.23 0.67 0.97 0.88 1.08 0.65 3907
rs933360 A 7 GRB10 intron 1.03 0.87 1.22 0.70 1.03 0.93 1.14 0.54 3905
rs6943153 C 7 GRB10 intron 0.86 0.73 1.03 0.11 0.95 0.86 1.05 0.36 3602
rs516946 C 8 ANK1 intron 1.01 0.82 1.23 0.91 1.09 0.97 1.23 0.13 3922
rs896854 T 8 TP53INP1 intron 0.97 0.83 1.14 0.75 0.97 0.88 1.06 0.57 3903
rs7034200 A 9 GLIS3 intron 0.98 0.83 1.15 0.84 1.03 0.93 1.13 0.52 3868
rs13292136 C 9 TLE4 (CHCHD9) intergenic 0.94 0.75 1.18 0.62 0.98 0.86 1.12 0.79 3706
rs12571751 A 10 ZMIZ1 intron 0.86 0.73 1.01 0.07 0.96 0.87 1.06 0.49 3601
rs553668 A 10 ADRA2A UTR-3 1.17 0.99 1.39 0.06 1.07 0.97 1.19 0.15 3666
rs10885122 G 10 ADRA2A intergenic 1.03 0.84 1.27 0.75 1.05 0.93 1.18 0.42 3683
rs163184 G 11 KCNQ1 intron 0.90 0.76 1.07 0.23 1.00 0.90 1.10 0.98 3713
rs2237895 C 11 KCNQ1 intron 0.96 0.81 1.13 0.66 1.01 0.92 1.11 0.79 3682
rs11605924 A 11 CRY2 intron 0.84 0.72 0.97 0.025 1.00 0.92 1.10 0.85 3909
rs7944584 A 11 MADD intron 0.91 0.74 1.13 0.41 1.09 0.96 1.23 0.15 3553
rs174550 T 11 FADS1 intron 0.94 0.76 1.17 0.62 0.96 0.85 1.09 0.56 3908
rs1552224 A 11 CENTD2 intergenic 0.92 0.75 1.13 0.45 0.81 0.72 0.92 0.001 3911
rs11063069 G 12 CCND2 intergenic 0.99 0.80 1.23 0.98 1.04 0.91 1.19 0.52 3671
rs10842994 C 12 KLHDC5 intergenic 1.13 0.89 1.44 0.28 0.97 0.84 1.11 0.67 3906
rs1153188 A 12 DCD intergenic 1.15 0.93 1.42 0.19 1.01 0.89 1.14 0.82 3912
rs1531343 C 12 HMGA2 intron of pseudogene 0.83 0.67 1.03 0.09 0.90 0.80 1.02 0.10 3915
rs7961581 C 12 TSPAN8,LGR5 intergenic 0.91 0.77 1.08 0.31 1.02 0.92 1.13 0.61 3703
rs7957197 T 12 OASL/TCF1/HNF1A intron of QASL 0.87 0.65 1.17 0.37 1.00 0.83 1.21 0.96 3924
rs17271305 G 15 VPS13C intron 1.02 0.86 1.20 0.81 0.92 0.83 1.02 0.15 3825
rs11071657 A 15 FAM148B intergenic 1.03 0.87 1.22 0.72 0.92 0.83 1.02 0.13 3897
rs7177055 A 15 HMG20A intergenic 1.00 0.85 1.17 0.99 0.98 0.89 1.08 0.74 3907
rs35767 G 12 IGF1 nearGene-5 0.88 0.91 1.10 0.19 0.93 0.94 1.06 0.21 3910
rs11634397 G 15 ZFAND6 intergenic 0.89 0.76 1.04 0.16 0.96 0.87 1.06 0.47 3910
rs8042680 A 15 PRC1 intron 0.89 0.76 1.04 0.16 0.99 0.90 1.10 0.95 3887
rs8090011 G 18 LAMA1 intron 0.95 0.81 1.11 0.57 0.93 0.84 1.02 0.13 3911
rs10401969 C 19 SUGP1 intron 0.96 0.72 1.27 0.79 0.86 0.72 1.01 0.07 3605
rs8108269 G 19 GIPR intergenic 1.02 0.85 1.23 0.77 1.07 0.96 1.19 0.16 3508
rs10423928 A 19 GIPR intron 0.85 0.67 1.08 0.20 1.06 0.93 1.20 0.37 3911
rs6017317 G 20 FITM2-R3HDML-HNF4A intergenic 0.96 0.81 1.13 0.64 0.98 0.89 1.08 0.72 3758
rs5945326 A X DUSP9 intergenic 0.95 0.81 1.12 0.58 1.01 0.92 1.12 0.74 3589
  1. EA effect allele, OR_WHO1999 odds ratio based on WHO1999 criteria, OR_WHO2013 Odds ratio based on WHO2013 criteria, CI confidence interval
  2. significant p values where p < 0.05 are indicated in bold