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Table 1 Under and overexpressed proteins identified by one-dimensional gel electrophoresis (1-DE) in metastatic (N+) and non-metastatic (N0) lymph nodes from laryngeal SCC patients. Proteins were separated by one-dimensional gel electrophoresis and identified by Q-TOF MS and Scaffold software according to quantitative value. Thirty-nine proteins with a fold change of at least 2.0 were considered with differential abundance between the categories

From: Differentially expressed proteins in positive versus negative HNSCC lymph nodes

Protein name

Gene symbol

UniProt accession

Quantitative value

Fold change

N+

N+

N0

N+/N0

Actin, cytoplasmic 1

ACTB

P60709

1

8

0.1

Down

Serum albumin

ALB

P02768

2

14

0.1

Down

Apolipoprotein A-I

APOA1

P02647

0

10

< 2.0

Down

Rho GDP-dissociation inhibitor 1

ARHGDIA

P52565

0

2

< 2.0

Down

Rho GDP-dissociation inhibitor 2

ARHGDIB

P52566

0

4

< 2.0

Down

Flavin reductase (NADPH)

BLVRB

P30043

0

3

< 2.0

Down

Carbonic anhydrase 1

CA1

P00915

0

2

< 2.0

Down

Coactosin-like protein

COTL1

Q14019

0

2

< 2.0

Down

Glyceraldehyde-3-phosphate dehydrogenase

GAPDH

P04406

1

2

0.5

Down

Glutathione S-transferase P

GSTP1

P09211

0

2

< 2.0

Down

Hemoglobin subunit alpha

HBA1/HBA2

P69905

0

28

< 2.0

Down

Hemoglobin subunit beta

HBB

P68871

0

10

< 2.0

Down

Hemoglobin subunit delta

HBD

P02042

0

17

< 2.0

Down

Histone H2A type 1-A

HIST1H2AA

Q96QV6

0

2

< 2.0

Down

Histone H2B type 1-C/E/F/G/I

HIST1H2BG

P62807

0

3

< 2.0

Down

Histone H3.1

HIST1H3A

P68431

0

4

< 2.0

Down

Heat shock protein beta-1

HSPB1

P04792

0

3

< 2.0

Down

Keratin, type II cytoskeletal 1

KRT1

P04264

0

3

< 2.0

Down

Keratin, type I cytoskeletal 9

KRT9

P35527

0

2

< 2.0

Down

Myosin light polypeptide 6

MYL6

P60660

0

2

< 2.0

Down

Protein deglycase DJ-1

PARK7

Q99497

0

3

< 2.0

Down

Profilin-1

PFN1

P07737

0

5

< 2.0

Down

Peptidyl-prolyl cis-trans isomerase A

PPIA

P62937

1

6

0.2

Down

Peroxiredoxin-1

PRDX1

Q06830

1

6

0.2

Down

Peroxiredoxin-2

PRDX2

P32119

0

5

< 2.0

Down

Peroxiredoxin-6

PRDX6

P30041

0

2

< 2.0

Down

Proteasome subunit beta type-5

PSMB5

P28074

0

2

< 2.0

Down

Ras-related protein Rab-10

RAB10

P61026

1

2

0.5

Down

Ras-related protein Rab-5B

RAB5B

P61020

0

2

< 2.0

Down

Ras-related protein Rap-1A

RAP1A

P62834

0

2

< 2.0

Down

Transgelin-2

TAGLN2

P37802

0

2

< 2.0

Down

Triosephosphate isomerase

TPI1

P60174

2

11

0.2

Down

14–3-3 protein beta/alpha

YWHAB

P31946

0

7

< 2.0

Down

14–3-3 protein zeta/delta

YWHAZ

P63104

3

10

0.3

Down

Annexin A1

ANXA1

P04083

4

0

> 2.0

Up

Keratin, type I cytoskeletal 13

KRT13

P13646

3

0

> 2.0

Up

Keratin, type II cytoskeletal 6A

KRT6A

P02538

4

0

> 2.0

Up

Periostin

POSTN

Q15063

2

0

> 2.0

Up

Protein S100-A9

S100A9

P06702

10

0

> 2.0

Up