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Table 1 Under and overexpressed proteins identified by one-dimensional gel electrophoresis (1-DE) in metastatic (N+) and non-metastatic (N0) lymph nodes from laryngeal SCC patients. Proteins were separated by one-dimensional gel electrophoresis and identified by Q-TOF MS and Scaffold software according to quantitative value. Thirty-nine proteins with a fold change of at least 2.0 were considered with differential abundance between the categories

From: Differentially expressed proteins in positive versus negative HNSCC lymph nodes

Protein name Gene symbol UniProt accession Quantitative value Fold change N+
N+ N0 N+/N0
Actin, cytoplasmic 1 ACTB P60709 1 8 0.1 Down
Serum albumin ALB P02768 2 14 0.1 Down
Apolipoprotein A-I APOA1 P02647 0 10 < 2.0 Down
Rho GDP-dissociation inhibitor 1 ARHGDIA P52565 0 2 < 2.0 Down
Rho GDP-dissociation inhibitor 2 ARHGDIB P52566 0 4 < 2.0 Down
Flavin reductase (NADPH) BLVRB P30043 0 3 < 2.0 Down
Carbonic anhydrase 1 CA1 P00915 0 2 < 2.0 Down
Coactosin-like protein COTL1 Q14019 0 2 < 2.0 Down
Glyceraldehyde-3-phosphate dehydrogenase GAPDH P04406 1 2 0.5 Down
Glutathione S-transferase P GSTP1 P09211 0 2 < 2.0 Down
Hemoglobin subunit alpha HBA1/HBA2 P69905 0 28 < 2.0 Down
Hemoglobin subunit beta HBB P68871 0 10 < 2.0 Down
Hemoglobin subunit delta HBD P02042 0 17 < 2.0 Down
Histone H2A type 1-A HIST1H2AA Q96QV6 0 2 < 2.0 Down
Histone H2B type 1-C/E/F/G/I HIST1H2BG P62807 0 3 < 2.0 Down
Histone H3.1 HIST1H3A P68431 0 4 < 2.0 Down
Heat shock protein beta-1 HSPB1 P04792 0 3 < 2.0 Down
Keratin, type II cytoskeletal 1 KRT1 P04264 0 3 < 2.0 Down
Keratin, type I cytoskeletal 9 KRT9 P35527 0 2 < 2.0 Down
Myosin light polypeptide 6 MYL6 P60660 0 2 < 2.0 Down
Protein deglycase DJ-1 PARK7 Q99497 0 3 < 2.0 Down
Profilin-1 PFN1 P07737 0 5 < 2.0 Down
Peptidyl-prolyl cis-trans isomerase A PPIA P62937 1 6 0.2 Down
Peroxiredoxin-1 PRDX1 Q06830 1 6 0.2 Down
Peroxiredoxin-2 PRDX2 P32119 0 5 < 2.0 Down
Peroxiredoxin-6 PRDX6 P30041 0 2 < 2.0 Down
Proteasome subunit beta type-5 PSMB5 P28074 0 2 < 2.0 Down
Ras-related protein Rab-10 RAB10 P61026 1 2 0.5 Down
Ras-related protein Rab-5B RAB5B P61020 0 2 < 2.0 Down
Ras-related protein Rap-1A RAP1A P62834 0 2 < 2.0 Down
Transgelin-2 TAGLN2 P37802 0 2 < 2.0 Down
Triosephosphate isomerase TPI1 P60174 2 11 0.2 Down
14–3-3 protein beta/alpha YWHAB P31946 0 7 < 2.0 Down
14–3-3 protein zeta/delta YWHAZ P63104 3 10 0.3 Down
Annexin A1 ANXA1 P04083 4 0 > 2.0 Up
Keratin, type I cytoskeletal 13 KRT13 P13646 3 0 > 2.0 Up
Keratin, type II cytoskeletal 6A KRT6A P02538 4 0 > 2.0 Up
Periostin POSTN Q15063 2 0 > 2.0 Up
Protein S100-A9 S100A9 P06702 10 0 > 2.0 Up