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Table 2 Under and overexpressed proteins identified by two-dimensional gel electrophoresis (2-DE) in metastatic (N+) and non-metastatic (N0) lymph nodes from oral cavity SCC patients. Proteins were separated by two-dimensional electrophoresis and identified by MALDI-Q-TOF MS/MS. Twenty-two proteins were considered with differential abundance between the categories (Student’s t test p < 0.05). C02, C04, C32 columns correspond to pools from tongue (pools A and B), floor of the mouth (pools C and D) and larynx carcinomas (pools E and F), respectively. N+/N0: abundance ratio

From: Differentially expressed proteins in positive versus negative HNSCC lymph nodes

Protein name

Gene symbol

UniProt accession

pI

Mass

Sequence coverage (%)

Score

Queries matched

Areaa

C02

C04

C32

N+

N+/N0

Carbonic anhydrase 1 or CA-I

CA1

P00915

6.65

28,620

16

116

3

VII

0.4402

0.2033

0.2971

Down

Calreticulin or CRP55

CALR

P27797

4.29

48,283

9

167

3

IX

  

0.6211

Down

Hemoglobin subunit delta

HBD

P02042

7.97

16,028

19

64

2

IV

 

0.3906

0.1063

Down

Heat shock protein 90 kDa beta member 1 or endoplasmin

HSP90B1

P14625

4.76

92,696

4

69

3

I

0.4010

 

0.5364

Down

Cytosol aminopeptidase or LAP-3

LAP3

P28838

6.29

53,006

4

71

3

IX

0.4514

 

0.6685

Down

Protein disulfide-isomerase or PDI

P4HB

P07237

4.76

57,480

8

201

4

IX

  

0.6616

Down

Profilin-1

PFN1

P07737

8.48

15,085

10

50

2

IV

0.3568

0.4595

0.6419

Down

Triosephosphate isomerase or TIM

TPI1

P60174

6.51

26,807

8

51

1

VI

0.5020

0.3262

0.3373

Down

Aldo-keto reductase family 1 member B10 or ARL-1

AKR1B10

O60218

7.12

36,226

12

149

3

II

3.7339

2.2564

 

Up

Apolipoprotein A-I or Apo-AI

APOA1

P02647

5.56

30,759

11

104

3

VI

 

1.5333

 

Up

Cystatin-B or CPI-B

CSTB

P04080

7.90

11,224

24

64

2

XI

2.0971

1.9614

 

Up

Fatty acid-binding protein, epidermal or E-FABP

FABP5

Q01469

6.84

15,366

18

94

2

VIII

4.0016

7.4081

5.5954

Up

Glutathione S-transferase P or GSTP1–1

GSTP1

P09211

5.44

23,438

12

78

2

VI

2.3289

4.0385

2.9731

Up

Heat shock protein beta-1 or HspB1

HSPB1

P04792

5.98

22,826

20

105

3

III

3.2028

4.1256

4.5202

Up

Ig gamma-1 chain C region

IGHG1

P01857

8.46

36,596

9

71

2

X

4.1259

 

4.3046

Up

Ig kappa chain C region

IGKC

P01834

7.55

26,077

14

48

2

VII

 

2.5279

2.1303

Up

Keratin, type II cytoskeletal 1 or CK1

KRT1

P04264

8.16

66,018

4

82

2

VII

 

1.7525

2.0958

Up

Galectin-1 or Gal-1

LGALS1

P09382

5.34

14,917

8

54

1

V

1.8654

2.2229

1.4698

Up

Galectin-7 or Gal-7

LGALS7B

P47929

7.00

14,992

19

73

2

VIII

6.2867

2.5605

2.7244

Up

Protein S100-A7 or psoriasin

S100A7

P31151

6.26

11,433

34

103

3

VIII

6.4075

9.3486

5.3993

Up

Protein S100-A9 or calgranulin-B

S100A9

P06702

5.71

13,291

42

100

3

VIII

4.7500

5.9737

4.9505

Up

14–3-3 protein sigma or stratifin

SFN

P31947

4.64

27,874

15

98

3

III

13.4829

7.3989

27.6468

Up

  1. aAreas are numbered as in Additional file 1
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BMC Medical Genomics

ISSN: 1755-8794

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