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Table 1 Patients’ characteristics and acceptance of the return of secondary germline Medically Actionable Variants

From: Additional germline findings from a tumor profiling program

 

Accepted n = 1844

Declined n = 103

p-value †

Age– years (mean)

57.6

57.6

> 0.95

Gender - n

p-value ‡

 Female

1235 (67%)

71 (69%)

> 0.68

 Male

609 (33%)

32 (31%)

Race - n

 White

1003 (54%)

56 (54%)

> 0.95

 Asian

207 (11%)

16 (16%)

 Black

35 (2%)

1 (1%)

 Mixed

14 (1%)

0 (0%)

 Unknown

585 (32%)

30 (29%)

Cancer site - n

 Gynecological

518 (28%)

25 (24%)

0.015

 Gastrointestinal

382 (21%)

19 (18%)

 Breast

233 (13%)

18 (17%)

 Lung

227 (12%)

17 (17%)

 Pancreas

194 (11%)

8 (8%)

 Sarcoma

21 (1%)

5 (5%)

 Others

269 (15%)

11(11%)

Prior genetic testing - n

 Yes

345 (19%)

15 (15%)

0.292

 No

1499 (81%)

88 (85%)

ECOG - n

 0

760 (41%)

37 (36%)

0.288

 1

1084 (59%)

66 (64%)

  1. ECOG The Eastern Cooperative Oncology Group, n number. Values are expressed as mean (+/− standard deviation), except otherwise stated. †. T-d’Student test; ‡. Chi square test