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Fig. 3 | BMC Medical Genomics

Fig. 3

From: Multiple occurrence of psychomotor retardation and recurrent miscarriages in a family with a submicroscopic reciprocal translocation t(7;17)(p22;p13.2)

Fig. 3

a Karyogram of the proband father III/13, carrier of the balanced translocation; t(7;17)(p22;p13.2). The arrows indicate abnormal chromosomes 7 and 17. b Metaphase spread of patient III/13 stained by FISH technique with a probe specific for the critical region of Miller–Dieker syndrome (17p13.3—LIS1, red) and the critical region of Smith–Magenis syndrome (17p11.2—RAI1, green). The arrows indicate the abnormal chromosomes 7 and 17. c Metaphase spread of the patient III/13 stained by FISH technique with a probe specific for the subtelomere of chromosome 7 short arm (red) and a probe specific for the subtelomere of chromosome 17 short arm (green). The longer arrow indicates the abnormal chromosome 7 with two signals from chromosome 7 and chromosome 17 subtelomeres. The shouter arrow indicates chromosome 17 without subtelomere signal. d Metaphase spread of the patient III/13 stained by FISH technique with a probe specific for the TP53 gene (17p13.1, red) and chromosome 17 centromere (green). The number and localization of signals are normal

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