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Table 1 Demographics and clinical features of the study participants

From: Circulating miRNome profiling in Moyamoya disease-discordant monozygotic twins and endothelial microRNA expression analysis using iPS cell line

  Age (y) Sex Disease type Disease stage Familial MMD EC/IC bypass Comorbidity Brain lesion rs112735431 (RNF213)
at sampling at onset
Circulating miRNome microarray analysis
MMD-Discordant Monozygotic Twins
Affected Twin 12 3 F TIA 3 Yes Yes No No AG
Non-affected Twin 12 F Yes No No AG
Non-Twin cohort
MMD, n = 9 49.7 ± 5.4 37.3 ± 7.3 66.7% All TIA 3 56.0% 100% 11% 67% All AG
Control, n = 10 51.7 ± 3.6 70% 0% 0% 0% All GG
P-value 0.75   1.0        
iPSEC-microRNA and gene expression analysis
MMD, n = 3 41.0 ± 3.6 39.1 ± 4.0 67% All TIA 3 TIA 67% 33% 0% All AG
Control, n = 3 50.0 ± 2.0 0% 0% 0% 0% All GG
  1. Disease stage indicates MRA grade of the advanced hemisphere if a difference between hemispheres exists. Comorbidity observed in study participants was hypertension. Age (years) was expressed as the mean ± SEM and Disease stage was expressed as median in the non-twin cohort. F female, EC/IC bypass: extracranial-intracranial bypass, TIA transient ischemic attack. A: minor and G: major allele for rs112735431 of the RNF213 gene