| Age (y) | Sex | Disease type | Disease stage | Familial MMD | EC/IC bypass | Comorbidity | Brain lesion | rs112735431 (RNF213) | |
---|---|---|---|---|---|---|---|---|---|---|
at sampling | at onset | |||||||||
Circulating miRNome microarray analysis | ||||||||||
MMD-Discordant Monozygotic Twins | ||||||||||
Affected Twin | 12 | 3 | F | TIA | 3 | Yes | Yes | No | No | AG |
Non-affected Twin | 12 | – | F | – | – | Yes | – | No | No | AG |
Non-Twin cohort | ||||||||||
MMD, n = 9 | 49.7 ± 5.4 | 37.3 ± 7.3 | 66.7% | All TIA | 3 | 56.0% | 100% | 11% | 67% | All AG |
Control, n = 10 | 51.7 ± 3.6 | – | 70% | – | – | 0% | 0% | 0% | – | All GG |
P-value | 0.75 | Â | 1.0 | Â | Â | Â | Â | Â | Â | Â |
iPSEC-microRNA and gene expression analysis | ||||||||||
MMD, n = 3 | 41.0 ± 3.6 | 39.1 ± 4.0 | 67% | All TIA | 3 | TIA | 67% | 33% | 0% | All AG |
Control, n = 3 | 50.0 ± 2.0 | – | 0% | – | – | 0% | 0% | 0% | – | All GG |