Skip to main content

Table 1 Demographics and clinical features of the study participants

From: Circulating miRNome profiling in Moyamoya disease-discordant monozygotic twins and endothelial microRNA expression analysis using iPS cell line

 

Age (y)

Sex

Disease type

Disease stage

Familial MMD

EC/IC bypass

Comorbidity

Brain lesion

rs112735431 (RNF213)

at sampling

at onset

Circulating miRNome microarray analysis

MMD-Discordant Monozygotic Twins

Affected Twin

12

3

F

TIA

3

Yes

Yes

No

No

AG

Non-affected Twin

12

–

F

–

–

Yes

–

No

No

AG

Non-Twin cohort

MMD, n = 9

49.7 ± 5.4

37.3 ± 7.3

66.7%

All TIA

3

56.0%

100%

11%

67%

All AG

Control, n = 10

51.7 ± 3.6

–

70%

–

–

0%

0%

0%

–

All GG

P-value

0.75

 

1.0

       

iPSEC-microRNA and gene expression analysis

MMD, n = 3

41.0 ± 3.6

39.1 ± 4.0

67%

All TIA

3

TIA

67%

33%

0%

All AG

Control, n = 3

50.0 ± 2.0

–

0%

–

–

0%

0%

0%

–

All GG

  1. Disease stage indicates MRA grade of the advanced hemisphere if a difference between hemispheres exists. Comorbidity observed in study participants was hypertension. Age (years) was expressed as the mean ± SEM and Disease stage was expressed as median in the non-twin cohort. F female, EC/IC bypass: extracranial-intracranial bypass, TIA transient ischemic attack. A: minor and G: major allele for rs112735431 of the RNF213 gene