TY - JOUR AU - Crawford, Dana C. AU - Restrepo, Nicole A. AU - Diggins, Kirsten E. AU - Farber-Eger, Eric AU - Wells, Quinn S. PY - 2018 DA - 2018/09/14 TI - Frequency and phenotype consequence of APOC3 rare variants in patients with very low triglyceride levels JO - BMC Medical Genomics SP - 66 VL - 11 IS - 3 AB - High levels of triglycerides (TG ≥200 mg/dL) are an emerging risk factor for cardiovascular disease. Conversely, very low levels of TG are associated with decreased risk for cardiovascular disease. Precision medicine aims to capitalize on recent findings that rare variants such as APOC3 R19X (rs76353203) are associated with risk of disease, but it is unclear how population-based associations can be best translated in clinical settings at the individual-patient level. SN - 1755-8794 UR - https://doi.org/10.1186/s12920-018-0387-1 DO - 10.1186/s12920-018-0387-1 ID - Crawford2018 ER -