Frequency and phenotype consequence of APOC3 rare variants in patients with very low triglyceride levels

Table 3 Genetic risk scores, unweighted and weighted, by case status among European American patients with very low triglyceride levels

	All patients with very low TG levels (n = 184)	Patients with no evidence of MI, revascularization, or other heart disease (n = 144)	Patients with evidence of MI (n = 26)	Patients with evidence of revascularization (n = 15)	Patients with evidence of other heart disease (n = 23)	Patients with evidence of MI, revascularization, and other heart disease (n = 6)
Unweighted GRS	38.97 (3.36)	38.78 (3.36)	39.46 (3.47)	39.07 (3.95)	39.08 (3.57)	38.00 (4.38)
Weighted GRS	41.97 (3.63)	41.77 (3.63)	42.54 (3.72)	42.08 (4.32)	42.14 (3.82)	41.02 (4.84)

We calculated unweighted and weighted genetic risk scores (GRS) based on 37 SNPs and previous association estimates in European Americans with and without coronary artery disease (Additional file 1: Table S1). Unweighted GRS were calculated as counts of risk alleles per patient, and weighted GRS were calculated using the pooled odds ratios from CARDIoGRAM [15]. Shown are the means (standard deviations) for unweighted and weighted GRS for the total study population as well as by cases status. Although unweighted and weighted GRS were higher among all patient groups with events or other heart conditions compared with patients lacking evidence of events or other heart disease, these differences were not statistically significant (unpaired t-tests; p > 0.05)